Torres-Santos EC - Search Results

1

Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.

Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR. Buarque CD, et al. Bioorg Med Chem. 2011 Nov 15;19(22):6885-91. doi: 10.1016/j.bmc.2011.09.025. Epub 2011 Sep 21. Bioorg Med Chem. 2011. PMID: 22000949 Free article.

2

Synthesis of chalcone analogues with increased antileishmanial activity.

Boeck P, Bandeira Falcão CA, Leal PC, Yunes RA, Filho VC, Torres-Santos EC, Rossi-Bergmann B. Boeck P, et al. Bioorg Med Chem. 2006 Mar 1;14(5):1538-45. doi: 10.1016/j.bmc.2005.10.005. Epub 2005 Dec 28. Bioorg Med Chem. 2006. PMID: 16386424

3

Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.

da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC. da Cunha-Júnior EF, et al. J Antimicrob Chemother. 2011 Jul;66(7):1555-9. doi: 10.1093/jac/dkr158. Epub 2011 Apr 29. J Antimicrob Chemother. 2011. PMID: 21531758

4

The pharmacological inhibition of sterol biosynthesis in Leishmania is counteracted by enhancement of LDL endocytosis.

Andrade-Neto VV, Cicco NN, Cunha-Junior EF, Canto-Cavalheiro MM, Atella GC, Torres-Santos EC. Andrade-Neto VV, et al. Acta Trop. 2011 Aug;119(2-3):194-8. doi: 10.1016/j.actatropica.2011.05.001. Epub 2011 May 13. Acta Trop. 2011. PMID: 21601554 Free article.

5

LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.

Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC. Ribeiro GA, et al. J Antimicrob Chemother. 2013 Apr;68(4):789-99. doi: 10.1093/jac/dks498. Epub 2013 Jan 3. J Antimicrob Chemother. 2013. PMID: 23288404

6

Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of Leishmania amazonensis.

dos Santos Faiões V, Leon LL, Canto-Cavalheiro MM, Torres-Santos EC, Bernardino AM, Vegi PF, dos Santos MS. dos Santos Faiões V, et al. Chem Biol Drug Des. 2014 Mar;83(3):272-7. doi: 10.1111/cbdd.12235. Epub 2013 Oct 30. Chem Biol Drug Des. 2014. PMID: 24119090

7

The new pyrazolyltetrazole derivative MSN20 is effective via oral delivery against cutaneous leishmaniasis.

Faiões Vdos S, Dos Santos MS, Bernardino AM, Cunha-Júnior EF, Canto Cavalheiro MM, Torres-Santos EC. Faiões Vdos S, et al. Antimicrob Agents Chemother. 2014 Oct;58(10):6290-3. doi: 10.1128/AAC.02874-14. Epub 2014 Aug 4. Antimicrob Agents Chemother. 2014. PMID: 25092697 Free PMC article.

8

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters.

Costa L, Pinheiro RO, Dutra PM, Santos RF, Cunha-Júnior EF, Torres-Santos EC, da Silva AJ, Costa PR, Da-Silva SA. Costa L, et al. PLoS One. 2014 Oct 23;9(10):e109672. doi: 10.1371/journal.pone.0109672. eCollection 2014. PLoS One. 2014. PMID: 25340550 Free PMC article.

9

Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis.

de Melos JL, Torres-Santos EC, Faiões Vdos S, Del Cistia Cde N, Sant'Anna CM, Rodrigues-Santos CE, Echevarria A. de Melos JL, et al. Eur J Med Chem. 2015 Oct 20;103:409-17. doi: 10.1016/j.ejmech.2015.09.009. Epub 2015 Sep 8. Eur J Med Chem. 2015. PMID: 26375353

10

Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis.

Cunha-Júnior EF, Martins TM, Canto-Cavalheiro MM, Marques PR, Portari EA, Coelho MG, Netto CD, Costa PR, Sabino KC, Torres-Santos EC. Cunha-Júnior EF, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3794-801. doi: 10.1128/AAC.01787-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27067332 Free PMC article.

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