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Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.
Harrison A, Gardner I, Hay T, Dickins M, Beaumont K, Phipps A, Purkins L, Allan G, Christian R, Duckworth J, Gurrell I, Kempshall S, Savage M, Seymour M, Simpson M, Taylor L, Turnpenny P. Harrison A, et al. Among authors: beaumont k. Xenobiotica. 2012 Jan;42(1):57-74. doi: 10.3109/00498254.2011.622418. Epub 2011 Oct 12. Xenobiotica. 2012. PMID: 21992032 Clinical Trial.
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
Jones HM, Butt RP, Webster RW, Gurrell I, Dzygiel P, Flanagan N, Fraier D, Hay T, Iavarone LE, Luckwell J, Pearce H, Phipps A, Segelbacher J, Speed B, Beaumont K. Jones HM, et al. Among authors: beaumont k. Clin Pharmacokinet. 2016 Jul;55(7):875-887. doi: 10.1007/s40262-015-0365-0. Clin Pharmacokinet. 2016. PMID: 26895021 Clinical Trial.
Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations.
Harrison A, Betts A, Fenner K, Beaumont K, Edgington A, Roffey S, Davis J, Comby P, Morgan P. Harrison A, et al. Among authors: beaumont k. Drug Metab Dispos. 2004 Feb;32(2):197-204. doi: 10.1124/dmd.32.2.197. Drug Metab Dispos. 2004. PMID: 14744941 Clinical Trial.
Bioanalytical data in decision making: discovery and development.
Smith DA, Beaumont K, Cussans NJ, Humphrey MJ, Jezequel SG, Rance DJ, Stopher DA, Walker DK. Smith DA, et al. Among authors: beaumont k. Xenobiotica. 1992 Sep-Oct;22(9-10):1195-205. doi: 10.3109/00498259209051873. Xenobiotica. 1992. PMID: 1441610 Review.
219 results