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Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Tsui AK, et al. Among authors: heximer sp. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17544-9. doi: 10.1073/pnas.1114026108. Epub 2011 Oct 5. Proc Natl Acad Sci U S A. 2011. PMID: 21976486 Free PMC article.
Metoprolol impairs resistance artery function in mice.
El Beheiry MH, Heximer SP, Voigtlaender-Bolz J, Mazer CD, Connelly KA, Wilson DF, Beattie WS, Tsui AK, Zhang H, Golam K, Hu T, Liu E, Lidington D, Bolz SS, Hare GM. El Beheiry MH, et al. Among authors: heximer sp. J Appl Physiol (1985). 2011 Oct;111(4):1125-33. doi: 10.1152/japplphysiol.01340.2010. Epub 2011 Jul 28. J Appl Physiol (1985). 2011. PMID: 21799135 Free PMC article.
Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.
Meissner A, Yang J, Kroetsch JT, Sauvé M, Dax H, Momen A, Noyan-Ashraf MH, Heximer S, Husain M, Lidington D, Bolz SS. Meissner A, et al. Circulation. 2012 Jun 5;125(22):2739-50. doi: 10.1161/CIRCULATIONAHA.111.047316. Epub 2012 Apr 25. Circulation. 2012. PMID: 22534621
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.
Yang J, Noyan-Ashraf MH, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS. Yang J, et al. Among authors: heximer sp. Circulation. 2012 Jul 10;126(2):196-206. doi: 10.1161/CIRCULATIONAHA.111.039644. Epub 2012 Jun 5. Circulation. 2012. PMID: 22668972
Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Blaser MC, et al. Among authors: heximer sp. Circ Res. 2018 Feb 2;122(3):405-416. doi: 10.1161/CIRCRESAHA.117.311194. Epub 2017 Dec 22. Circ Res. 2018. PMID: 29273600
B-Cell Deficiency Lowers Blood Pressure in Mice.
Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M. Dingwell LS, et al. Hypertension. 2019 Mar;73(3):561-570. doi: 10.1161/HYPERTENSIONAHA.118.11828. Hypertension. 2019. PMID: 30636551
CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage.
Lidington D, Fares JC, Uhl FE, Dinh DD, Kroetsch JT, Sauvé M, Malik FA, Matthes F, Vanherle L, Adel A, Momen A, Zhang H, Aschar-Sobbi R, Foltz WD, Wan H, Sumiyoshi M, Macdonald RL, Husain M, Backx PH, Heximer SP, Meissner A, Bolz SS. Lidington D, et al. Among authors: heximer sp. JACC Basic Transl Sci. 2019 Nov 27;4(8):940-958. doi: 10.1016/j.jacbts.2019.07.004. eCollection 2019 Dec. JACC Basic Transl Sci. 2019. PMID: 31909302 Free PMC article.
72 results