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Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.
Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL. Lu W, et al. Am J Hum Genet. 2007 Apr;80(4):616-32. doi: 10.1086/512735. Epub 2007 Feb 14. Am J Hum Genet. 2007. PMID: 17357069 Free PMC article.
NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.
Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL. Lu W, et al. PLoS Genet. 2007 May 25;3(5):e80. doi: 10.1371/journal.pgen.0030080. PLoS Genet. 2007. PMID: 17530927 Free PMC article.
Lower urinary tract development and disease.
Rasouly HM, Lu W. Rasouly HM, et al. Among authors: lu w. Wiley Interdiscip Rev Syst Biol Med. 2013 May-Jun;5(3):307-42. doi: 10.1002/wsbm.1212. Epub 2013 Feb 13. Wiley Interdiscip Rev Syst Biol Med. 2013. PMID: 23408557 Free PMC article. Review.
Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure.
Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH Jr, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Pisarek-Horowitz A, et al. Among authors: lu w. Am J Pathol. 2020 Apr;190(4):799-816. doi: 10.1016/j.ajpath.2019.12.009. Epub 2020 Mar 24. Am J Pathol. 2020. PMID: 32220420 Free PMC article.
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