Schols D - Search Results

1

Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

Metz M, Bourque E, Labrecque J, Danthi SJ, Langille J, Harwig C, Yang W, Darkes MC, Lau G, Santucci Z, Bridger GJ, Schols D, Fricker SP, Skerlj RT. Metz M, et al. Among authors: schols d. J Am Chem Soc. 2011 Oct 19;133(41):16477-85. doi: 10.1021/ja2043722. Epub 2011 Sep 23. J Am Chem Soc. 2011. PMID: 21942640

2

Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor.

Esté JA, Cabrera C, De Clercq E, Struyf S, Van Damme J, Bridger G, Skerlj RT, Abrams MJ, Henson G, Gutierrez A, Clotet B, Schols D. Esté JA, et al. Among authors: schols d. Mol Pharmacol. 1999 Jan;55(1):67-73. doi: 10.1124/mol.55.1.67. Mol Pharmacol. 1999. PMID: 9882699

3

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Struyf S, Witvrouw M, Schols D, De Clercq E. Bridger GJ, et al. Among authors: schols d. J Med Chem. 1999 Sep 23;42(19):3971-81. doi: 10.1021/jm990211i. J Med Chem. 1999. PMID: 10508445

4

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.

Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ. Lukacs NW, et al. Among authors: schols d. Am J Pathol. 2002 Apr;160(4):1353-60. doi: 10.1016/S0002-9440(10)62562-X. Am J Pathol. 2002. PMID: 11943720 Free PMC article.

5

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

Hatse S, Princen K, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: schols d. FEBS Lett. 2002 Sep 11;527(1-3):255-62. doi: 10.1016/s0014-5793(02)03143-5. FEBS Lett. 2002. PMID: 12220670 Free article.

6

The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.

Princen K, Hatse S, Vermeire K, Bridger GJ, Skerlj RT, De Clercq E, Schols D. Princen K, et al. Among authors: schols d. AIDS Res Hum Retroviruses. 2003 Dec;19(12):1135-9. doi: 10.1089/088922203771881239. AIDS Res Hum Retroviruses. 2003. PMID: 14709250

7

Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.

Princen K, Hatse S, Vermeire K, Aquaro S, De Clercq E, Gerlach LO, Rosenkilde M, Schwartz TW, Skerlj R, Bridger G, Schols D. Princen K, et al. Among authors: schols d. J Virol. 2004 Dec;78(23):12996-3006. doi: 10.1128/JVI.78.23.12996-13006.2004. J Virol. 2004. PMID: 15542651 Free PMC article.

8

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.

Hatse S, Princen K, De Clercq E, Rosenkilde MM, Schwartz TW, Hernandez-Abad PE, Skerlj RT, Bridger GJ, Schols D. Hatse S, et al. Among authors: schols d. Biochem Pharmacol. 2005 Sep 1;70(5):752-61. doi: 10.1016/j.bcp.2005.05.035. Biochem Pharmacol. 2005. PMID: 16011832 Free article.

9

Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.

Rosenkilde MM, Gerlach LO, Hatse S, Skerlj RT, Schols D, Bridger GJ, Schwartz TW. Rosenkilde MM, et al. Among authors: schols d. J Biol Chem. 2007 Sep 14;282(37):27354-27365. doi: 10.1074/jbc.M704739200. Epub 2007 Jun 28. J Biol Chem. 2007. PMID: 17599916 Free article.

10

Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication.

Bridger GJ, Skerlj RT, Hernandez-Abad PE, Bogucki DE, Wang Z, Zhou Y, Nan S, Boehringer EM, Wilson T, Crawford J, Metz M, Hatse S, Princen K, De Clercq E, Schols D. Bridger GJ, et al. Among authors: schols d. J Med Chem. 2010 Feb 11;53(3):1250-60. doi: 10.1021/jm901530b. J Med Chem. 2010. PMID: 20043638

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