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Chemopreventive effects of the dietary histone deacetylase inhibitor tributyrin alone or in combination with vitamin A during the promotion phase of rat hepatocarcinogenesis.
de Conti A, Kuroiwa-Trzmielina J, Horst MA, Bassoli BK, Chagas CE, Purgatto E, Cavalher FP, Camargo AA, Jordão AA Jr, Vannucchi H, Scolastici C, Ong TP, Moreno FS. de Conti A, et al. Among authors: kuroiwa trzmielina j. J Nutr Biochem. 2012 Aug;23(8):860-6. doi: 10.1016/j.jnutbio.2011.04.010. Epub 2011 Sep 21. J Nutr Biochem. 2012. PMID: 21940155
The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.
de Conti A, Tryndyak V, Koturbash I, Heidor R, Kuroiwa-Trzmielina J, Ong TP, Beland FA, Moreno FS, Pogribny IP. de Conti A, et al. Among authors: kuroiwa trzmielina j. Carcinogenesis. 2013 Aug;34(8):1900-6. doi: 10.1093/carcin/bgt124. Epub 2013 Apr 8. Carcinogenesis. 2013. PMID: 23568954
SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.
Kuroiwa-Trzmielina J, Wang F, Rapkins RW, Ward RL, Buchanan DD, Win AK, Clendenning M, Rosty C, Southey MC, Winship IM, Hopper JL, Jenkins MA, Olivier J, Hawkins NJ, Hitchins MP. Kuroiwa-Trzmielina J, et al. Clin Cancer Res. 2016 Dec 15;22(24):6266-6277. doi: 10.1158/1078-0432.CCR-15-2765. Epub 2016 Jun 7. Clin Cancer Res. 2016. PMID: 27267851 Free PMC article.
The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients.
McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP. McDonald KL, et al. Among authors: kuroiwa trzmielina j. Eur J Cancer. 2013 Jan;49(2):360-8. doi: 10.1016/j.ejca.2012.08.012. Epub 2012 Sep 10. Eur J Cancer. 2013. PMID: 22975219