Walker MW - Search Results

1

5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.

Packiarajan M, Coate H, Desai M, Jimenez HN, Reinhard EJ, Jubian VJ, Marzabadi MR, Chandrasena G, Wolinski TC, Walker MW, Andersen K. Packiarajan M, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6500-4. doi: 10.1016/j.bmcl.2011.08.072. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21924902

2

Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.

Konkel MJ, Packiarajan M, Chen H, Topiwala UP, Jimenez H, Talisman IJ, Coate H, Walker MW. Konkel MJ, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3950-4. doi: 10.1016/j.bmcl.2006.05.025. Epub 2006 May 30. Bioorg Med Chem Lett. 2006. PMID: 16730981

3

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.

Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K. Packiarajan M, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5436-41. doi: 10.1016/j.bmcl.2011.06.124. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782428

4

N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.

Wu L, Lu K, Desai M, Packiarajan M, Joshi A, Marzabadi MR, Jubian V, Andersen K, Chandrasena G, Boyle NJ, Walker MW. Wu L, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5573-6. doi: 10.1016/j.bmcl.2011.06.078. Epub 2011 Jun 25. Bioorg Med Chem Lett. 2011. PMID: 21782430

5

Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists.

Wu L, Lu K, Packiarajan M, Jubian V, Chandrasena G, Wolinsky TC, Walker MW. Wu L, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2167-71. doi: 10.1016/j.bmcl.2012.01.117. Epub 2012 Feb 4. Bioorg Med Chem Lett. 2012. PMID: 22361135

6

Discovery of potent and selective small molecule NPY Y5 receptor antagonists.

Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C. Islam I, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9. doi: 10.1016/s0960-894x(02)00287-1. Bioorg Med Chem Lett. 2002. PMID: 12067557

7

3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.

Konkel MJ, Lagu B, Boteju LW, Jimenez H, Noble S, Walker MW, Chandrasena G, Blackburn TP, Nikam SS, Wright JL, Kornberg BE, Gregory T, Pugsley TA, Akunne H, Zoski K, Wise LD. Konkel MJ, et al. Among authors: walker mw. J Med Chem. 2006 Jun 29;49(13):3757-8. doi: 10.1021/jm060001n. J Med Chem. 2006. PMID: 16789730

8

The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA. Walker MW, et al. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11. doi: 10.1124/jpet.108.144634. Epub 2008 Dec 19. J Pharmacol Exp Ther. 2009. PMID: 19098165

9

Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers.

Kumar JS, Walker M, Packiarajan M, Jubian V, Prabhakaran J, Chandrasena G, Pratap M, Parsey RV, Mann JJ. Kumar JS, et al. ACS Chem Neurosci. 2016 May 18;7(5):540-5. doi: 10.1021/acschemneuro.5b00315. Epub 2016 Feb 22. ACS Chem Neurosci. 2016. PMID: 26886507

10

High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.

Finn J, Pelham D, Walker MW, Gluchowski C. Finn J, et al. Among authors: walker mw. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1771-4. doi: 10.1016/s0960-894x(02)00288-3. Bioorg Med Chem Lett. 2002. PMID: 12067558

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