Packiarajan M - Search Results

1

5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.

Packiarajan M, Coate H, Desai M, Jimenez HN, Reinhard EJ, Jubian VJ, Marzabadi MR, Chandrasena G, Wolinski TC, Walker MW, Andersen K. Packiarajan M, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6500-4. doi: 10.1016/j.bmcl.2011.08.072. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21924902

2

Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.

Konkel MJ, Packiarajan M, Chen H, Topiwala UP, Jimenez H, Talisman IJ, Coate H, Walker MW. Konkel MJ, et al. Among authors: packiarajan m. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3950-4. doi: 10.1016/j.bmcl.2006.05.025. Epub 2006 May 30. Bioorg Med Chem Lett. 2006. PMID: 16730981

3

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.

Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K. Packiarajan M, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5436-41. doi: 10.1016/j.bmcl.2011.06.124. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782428

4

N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.

Wu L, Lu K, Desai M, Packiarajan M, Joshi A, Marzabadi MR, Jubian V, Andersen K, Chandrasena G, Boyle NJ, Walker MW. Wu L, et al. Among authors: packiarajan m. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5573-6. doi: 10.1016/j.bmcl.2011.06.078. Epub 2011 Jun 25. Bioorg Med Chem Lett. 2011. PMID: 21782430

5

Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists.

Wu L, Lu K, Packiarajan M, Jubian V, Chandrasena G, Wolinsky TC, Walker MW. Wu L, et al. Among authors: packiarajan m. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2167-71. doi: 10.1016/j.bmcl.2012.01.117. Epub 2012 Feb 4. Bioorg Med Chem Lett. 2012. PMID: 22361135

6

Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists.

Lu K, Jiang Y, Chen B, Eldemenky EM, Ma G, Packiarajan M, Chandrasena G, White AD, Jones KA, Li B, Hong SP. Lu K, et al. Among authors: packiarajan m. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5310-4. doi: 10.1016/j.bmcl.2011.07.020. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21802292

7

N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.

Packiarajan M, Mazza Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5658-62. doi: 10.1016/j.bmcl.2012.06.094. Epub 2012 Jul 6. Bioorg Med Chem Lett. 2012. PMID: 22832311

8

Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.

Packiarajan M, Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6469-74. doi: 10.1016/j.bmcl.2012.08.044. Epub 2012 Aug 25. Bioorg Med Chem Lett. 2012. PMID: 22975301

9

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.

Packiarajan M, Grenon M, Zorn S, Hopper AT, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4037-43. doi: 10.1016/j.bmcl.2013.05.070. Epub 2013 May 30. Bioorg Med Chem Lett. 2013. PMID: 23770058

10

Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers.

Kumar JS, Walker M, Packiarajan M, Jubian V, Prabhakaran J, Chandrasena G, Pratap M, Parsey RV, Mann JJ. Kumar JS, et al. Among authors: packiarajan m. ACS Chem Neurosci. 2016 May 18;7(5):540-5. doi: 10.1021/acschemneuro.5b00315. Epub 2016 Feb 22. ACS Chem Neurosci. 2016. PMID: 26886507

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