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Page 1
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K. Packiarajan M, et al. Among authors: chandrasena g. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5436-41. doi: 10.1016/j.bmcl.2011.06.124. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782428
N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.
Wu L, Lu K, Desai M, Packiarajan M, Joshi A, Marzabadi MR, Jubian V, Andersen K, Chandrasena G, Boyle NJ, Walker MW. Wu L, et al. Among authors: chandrasena g. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5573-6. doi: 10.1016/j.bmcl.2011.06.078. Epub 2011 Jun 25. Bioorg Med Chem Lett. 2011. PMID: 21782430
N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Packiarajan M, Mazza Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Among authors: chandrasena g. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5658-62. doi: 10.1016/j.bmcl.2012.06.094. Epub 2012 Jul 6. Bioorg Med Chem Lett. 2012. PMID: 22832311
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Packiarajan M, Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Among authors: chandrasena g. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6469-74. doi: 10.1016/j.bmcl.2012.08.044. Epub 2012 Aug 25. Bioorg Med Chem Lett. 2012. PMID: 22975301
Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
Packiarajan M, Grenon M, Zorn S, Hopper AT, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ. Packiarajan M, et al. Among authors: chandrasena g. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4037-43. doi: 10.1016/j.bmcl.2013.05.070. Epub 2013 May 30. Bioorg Med Chem Lett. 2013. PMID: 23770058
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Konkel MJ, Lagu B, Boteju LW, Jimenez H, Noble S, Walker MW, Chandrasena G, Blackburn TP, Nikam SS, Wright JL, Kornberg BE, Gregory T, Pugsley TA, Akunne H, Zoski K, Wise LD. Konkel MJ, et al. Among authors: chandrasena g. J Med Chem. 2006 Jun 29;49(13):3757-8. doi: 10.1021/jm060001n. J Med Chem. 2006. PMID: 16789730
43 results