Holas O - Search Results

1

Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.

Korabecny J, Musilek K, Zemek F, Horova A, Holas O, Nepovimova E, Opletalova V, Hroudova J, Fisar Z, Jung YS, Kuca K. Korabecny J, et al. Among authors: holas o. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6563-6. doi: 10.1016/j.bmcl.2011.08.042. Epub 2011 Aug 22. Bioorg Med Chem Lett. 2011. PMID: 21920739

2

Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M. Musilek K, et al. Among authors: holas o. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5673-6. doi: 10.1016/j.bmcl.2006.08.011. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934462

3

Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M. Musilek K, et al. Among authors: holas o. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3172-6. doi: 10.1016/j.bmcl.2007.03.025. Epub 2007 Mar 13. Bioorg Med Chem Lett. 2007. PMID: 17383875

4

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Kuca K. Musilek K, et al. Among authors: holas o. Bioorg Med Chem. 2007 Nov 1;15(21):6733-41. doi: 10.1016/j.bmc.2007.08.002. Epub 2007 Aug 10. Bioorg Med Chem. 2007. PMID: 17764957

5

Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

Korabecny J, Musilek K, Holas O, Binder J, Zemek F, Marek J, Pohanka M, Opletalova V, Dohnal V, Kuca K. Korabecny J, et al. Among authors: holas o. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. doi: 10.1016/j.bmcl.2010.08.044. Epub 2010 Aug 16. Bioorg Med Chem Lett. 2010. PMID: 20817518

6

Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.

Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V, Nachon F, Hroudova J, Fisar Z, Kuca K. Korabecny J, et al. Among authors: holas o. Molecules. 2010 Dec 2;15(12):8804-12. doi: 10.3390/molecules15128804. Molecules. 2010. PMID: 21127466 Free PMC article.

7

Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.

Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS. Musilek K, et al. Among authors: holas o. Bioorg Med Chem Lett. 2011 Jan 1;21(1):150-4. doi: 10.1016/j.bmcl.2010.11.051. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21144749

8

Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.

Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Kuca K. Musilek K, et al. Among authors: holas o. Bioorg Med Chem. 2011 Jan 15;19(2):754-62. doi: 10.1016/j.bmc.2010.12.021. Epub 2010 Dec 16. Bioorg Med Chem. 2011. PMID: 21215642

9

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.

Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K. Komloova M, et al. Among authors: holas o. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2505-9. doi: 10.1016/j.bmcl.2011.02.047. Epub 2011 Feb 21. Bioorg Med Chem Lett. 2011. PMID: 21397501

10

Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M. Musilek K, et al. Among authors: holas o. J Enzyme Inhib Med Chem. 2007 Aug;22(4):425-32. doi: 10.1080/14756360601164960. J Enzyme Inhib Med Chem. 2007. PMID: 17847708 Free article.

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