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CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. Yaddanapudi S, et al. Among authors: huber tb. J Clin Invest. 2011 Oct;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. J Clin Invest. 2011. PMID: 21911934 Free PMC article.
Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
Hartleben B, Schweizer H, Lübben P, Bartram MP, Möller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB. Hartleben B, et al. Among authors: huber tb. J Biol Chem. 2008 Aug 22;283(34):23033-8. doi: 10.1074/jbc.M803143200. Epub 2008 Jun 18. J Biol Chem. 2008. PMID: 18562307 Free PMC article.
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB. Hartleben B, et al. Among authors: huber tb. J Clin Invest. 2010 Apr;120(4):1084-96. doi: 10.1172/JCI39492. J Clin Invest. 2010. PMID: 20200449 Free PMC article.
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.
Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. Inoki K, et al. Among authors: huber tb. J Clin Invest. 2011 Jun;121(6):2181-96. doi: 10.1172/JCI44771. Epub 2011 May 23. J Clin Invest. 2011. PMID: 21606597 Free PMC article.
332 results