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Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo.
Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Intagliata S, et al. AAPS J. 2020 Jul 20;22(5):94. doi: 10.1208/s12248-020-00472-x. AAPS J. 2020. PMID: 32691179
The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands.
Stavitskaya L, Seminerio MJ, Matthews-Tsourounis MM, Matsumoto RR, Coop A. Stavitskaya L, et al. Among authors: seminerio mj. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2564-5. doi: 10.1016/j.bmcl.2010.02.087. Epub 2010 Mar 1. Bioorg Med Chem Lett. 2010. PMID: 20338757 Free PMC article.
35 results