Greenbaum DC - Search Results

1

The Trypanosoma cruzi protease cruzain mediates immune evasion.

Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. Among authors: greenbaum dc. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.

2

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

3

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. Mackey ZB, et al. Among authors: greenbaum dc. J Biol Chem. 2004 Nov 12;279(46):48426-33. doi: 10.1074/jbc.M402470200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326171 Free article.

4

Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.

Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Sajid M, et al. Mol Biochem Parasitol. 2003 Sep;131(1):65-75. doi: 10.1016/s0166-6851(03)00194-4. Mol Biochem Parasitol. 2003. PMID: 12967713

5

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

6

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.

Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M. Greenbaum DC, et al. Science. 2002 Dec 6;298(5600):2002-6. doi: 10.1126/science.1077426. Science. 2002. PMID: 12471262

7

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.

Greenbaum D, Medzihradszky KF, Burlingame A, Bogyo M. Greenbaum D, et al. Chem Biol. 2000 Aug;7(8):569-81. doi: 10.1016/s1074-5521(00)00014-4. Chem Biol. 2000. PMID: 11048948

8

Defining a link between gap junction communication, proteolysis, and cataract formation.

Baruch A, Greenbaum D, Levy ET, Nielsen PA, Gilula NB, Kumar NM, Bogyo M. Baruch A, et al. J Biol Chem. 2001 Aug 3;276(31):28999-9006. doi: 10.1074/jbc.M103628200. Epub 2001 Jun 6. J Biol Chem. 2001. PMID: 11395508 Free article.

9

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Harbut MB, Velmourougane G, Reiss G, Chandramohanadas R, Greenbaum DC. Harbut MB, et al. Among authors: greenbaum dc. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5932-6. doi: 10.1016/j.bmcl.2008.09.021. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18823778 Free PMC article.

10

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

Greenbaum DC, Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M. Greenbaum DC, et al. Chem Biol. 2002 Oct;9(10):1085-94. doi: 10.1016/s1074-5521(02)00238-7. Chem Biol. 2002. PMID: 12401493

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