Buck E - Search Results

1

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.

Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL. Fox EM, et al. Among authors: buck e. Cancer Res. 2011 Nov 1;71(21):6773-84. doi: 10.1158/0008-5472.CAN-11-1295. Epub 2011 Sep 9. Cancer Res. 2011. PMID: 21908557 Free PMC article.

2

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.

Buck E, Eyzaguirre A, Rosenfeld-Franklin M, Thomson S, Mulvihill M, Barr S, Brown E, O'Connor M, Yao Y, Pachter J, Miglarese M, Epstein D, Iwata KK, Haley JD, Gibson NW, Ji QS. Buck E, et al. Cancer Res. 2008 Oct 15;68(20):8322-32. doi: 10.1158/0008-5472.CAN-07-6720. Cancer Res. 2008. PMID: 18922904

3

Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer.

Buck E, Gokhale PC, Koujak S, Brown E, Eyzaguirre A, Tao N, Rosenfeld-Franklin M, Lerner L, Chiu MI, Wild R, Epstein D, Pachter JA, Miglarese MR. Buck E, et al. Mol Cancer Ther. 2010 Oct;9(10):2652-64. doi: 10.1158/1535-7163.MCT-10-0318. Epub 2010 Oct 5. Mol Cancer Ther. 2010. PMID: 20924128

4

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition.

Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N, Iwata KK, Gibson N, Haley JD. Thomson S, et al. Among authors: buck e. Cancer Res. 2005 Oct 15;65(20):9455-62. doi: 10.1158/0008-5472.CAN-05-1058. Cancer Res. 2005. PMID: 16230409

5

Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.

Zhao H, Desai V, Wang J, Epstein DM, Miglarese M, Buck E. Zhao H, et al. Among authors: buck e. Mol Cancer Ther. 2012 Feb;11(2):503-13. doi: 10.1158/1535-7163.MCT-11-0327. Epub 2011 Dec 9. Mol Cancer Ther. 2012. PMID: 22161861

6

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.

Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, Cooke A, Feng L, Mak G, O'Connor M, Yao Y, Pirritt C, Buck E, Eyzaguirre A, Arnold LD, Gibson NW, Pachter JA. Ji QS, et al. Among authors: buck e. Mol Cancer Ther. 2007 Aug;6(8):2158-67. doi: 10.1158/1535-7163.MCT-07-0070. Epub 2007 Aug 1. Mol Cancer Ther. 2007. PMID: 17671083

7

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.

Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, Buck E, Foreman K, Landfair D, O'Connor M, Pirritt C, Sun Y, Yao Y, Arnold LD, Gibson NW, Ji QS. Mulvihill MJ, et al. Among authors: buck e. Future Med Chem. 2009 Sep;1(6):1153-71. doi: 10.4155/fmc.09.89. Future Med Chem. 2009. PMID: 21425998

8

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer.

Buck E, Mulvihill M. Buck E, et al. Expert Opin Investig Drugs. 2011 May;20(5):605-21. doi: 10.1517/13543784.2011.558501. Epub 2011 Mar 30. Expert Opin Investig Drugs. 2011. PMID: 21446886 Review.

9

Small-molecule ATP-competitive dual IGF-1R and insulin receptor inhibitors: structural insights, chemical diversity and molecular evolution.

Jin M, Wang J, Buck E, Mulvihill MJ. Jin M, et al. Among authors: buck e. Future Med Chem. 2012 Mar;4(3):315-28. doi: 10.4155/fmc.11.180. Future Med Chem. 2012. PMID: 22393939 Review.

10

Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity.

Buck E, Eyzaguirre A, Haley JD, Gibson NW, Cagnoni P, Iwata KK. Buck E, et al. Mol Cancer Ther. 2006 Aug;5(8):2051-9. doi: 10.1158/1535-7163.MCT-06-0007. Mol Cancer Ther. 2006. PMID: 16928826

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