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Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?
Cheong SL, Dolzhenko AV, Paoletta S, Lee EP, Kachler S, Federico S, Klotz KN, Dolzhenko AV, Spalluto G, Moro S, Pastorin G. Cheong SL, et al. Among authors: pastorin g. Bioorg Med Chem. 2011 Oct 15;19(20):6120-34. doi: 10.1016/j.bmc.2011.08.026. Epub 2011 Aug 23. Bioorg Med Chem. 2011. PMID: 21908194
Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction.
Lim XC, Huang C, Yatim SMJM, Chong SY, Tan SH, Yang X, Heldt CL, Pedersen J, Talanker M, Modh H, Wacker MG, Pastorin G, Chan SP, Richards AM, Charles CJ, Chan MY, Wang JW. Lim XC, et al. Among authors: pastorin g. Int J Mol Sci. 2022 Dec 25;24(1):327. doi: 10.3390/ijms24010327. Int J Mol Sci. 2022. PMID: 36613770 Free PMC article.
Medicinal chemistry of A2A adenosine receptor antagonists.
Cacciari B, Pastorin G, Spalluto G. Cacciari B, et al. Among authors: pastorin g. Curr Top Med Chem. 2003;3(4):403-11. doi: 10.2174/1568026033392183. Curr Top Med Chem. 2003. PMID: 12570758 Review.
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
Pastorin G, Da Ros T, Spalluto G, Deflorian F, Moro S, Cacciari B, Baraldi PG, Gessi S, Varani K, Borea PA. Pastorin G, et al. J Med Chem. 2003 Sep 25;46(20):4287-96. doi: 10.1021/jm030852k. J Med Chem. 2003. PMID: 13678407
133 results