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The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation.
Buijs JT, van der Horst G, van den Hoogen C, Cheung H, de Rooij B, Kroon J, Petersen M, van Overveld PG, Pelger RC, van der Pluijm G. Buijs JT, et al. Among authors: van den hoogen c, van overveld pg, van der pluijm g, van der horst g. Oncogene. 2012 Apr 26;31(17):2164-74. doi: 10.1038/onc.2011.400. Epub 2011 Sep 26. Oncogene. 2012. PMID: 21996751
miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression.
Zoni E, van der Horst G, van de Merbel AF, Chen L, Rane JK, Pelger RC, Collins AT, Visakorpi T, Snaar-Jagalska BE, Maitland NJ, van der Pluijm G. Zoni E, et al. Among authors: van de merbel af, van der pluijm g, van der horst g. Cancer Res. 2015 Jun 1;75(11):2326-36. doi: 10.1158/0008-5472.CAN-14-2155. Epub 2015 Apr 9. Cancer Res. 2015. PMID: 25858144
Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.
Schwaninger R, Rentsch CA, Wetterwald A, van der Horst G, van Bezooijen RL, van der Pluijm G, Löwik CW, Ackermann K, Pyerin W, Hamdy FC, Thalmann GN, Cecchini MG. Schwaninger R, et al. Among authors: van der pluijm g, van der horst g, van bezooijen rl. Am J Pathol. 2007 Jan;170(1):160-75. doi: 10.2353/ajpath.2007.051276. Am J Pathol. 2007. PMID: 17200191 Free PMC article.
BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo.
Buijs JT, Rentsch CA, van der Horst G, van Overveld PG, Wetterwald A, Schwaninger R, Henriquez NV, Ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RC, Vukicevic S, Cecchini MG, Löwik CW, van der Pluijm G. Buijs JT, et al. Among authors: van overveld pg, van der pluijm g, van der horst g. Am J Pathol. 2007 Sep;171(3):1047-57. doi: 10.2353/ajpath.2007.070168. Am J Pathol. 2007. PMID: 17724140 Free PMC article.
High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer.
van den Hoogen C, van der Horst G, Cheung H, Buijs JT, Lippitt JM, Guzmán-Ramírez N, Hamdy FC, Eaton CL, Thalmann GN, Cecchini MG, Pelger RC, van der Pluijm G. van den Hoogen C, et al. Among authors: van der pluijm g, van der horst g. Cancer Res. 2010 Jun 15;70(12):5163-73. doi: 10.1158/0008-5472.CAN-09-3806. Epub 2010 Jun 1. Cancer Res. 2010. PMID: 20516116
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer.
van der Horst G, van den Hoogen C, Buijs JT, Cheung H, Bloys H, Pelger RC, Lorenzon G, Heckmann B, Feyen J, Pujuguet P, Blanque R, Clément-Lacroix P, van der Pluijm G. van der Horst G, et al. Among authors: van den hoogen c, van der pluijm g. Neoplasia. 2011 Jun;13(6):516-25. doi: 10.1593/neo.11122. Neoplasia. 2011. PMID: 21677875 Free PMC article.
323 results