Stewart LJ - Search Results

1

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.

Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ. Begley DW, et al. Among authors: stewart lj. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1060-9. doi: 10.1107/S1744309111014436. Epub 2011 Aug 13. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21904051 Free PMC article.

2

The mechanism of topoisomerase I poisoning by a camptothecin analog.

Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L. Staker BL, et al. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. doi: 10.1073/pnas.242259599. Epub 2002 Nov 8. Proc Natl Acad Sci U S A. 2002. PMID: 12426403 Free PMC article.

3

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Fox BM, et al. J Med Chem. 2003 Jul 17;46(15):3275-82. doi: 10.1021/jm0300476. J Med Chem. 2003. PMID: 12852757

4

Mechanisms of camptothecin resistance by human topoisomerase I mutations.

Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Chrencik JE, et al. J Mol Biol. 2004 Jun 11;339(4):773-84. doi: 10.1016/j.jmb.2004.03.077. J Mol Biol. 2004. PMID: 15165849

5

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.

Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB. Staker BL, et al. J Med Chem. 2005 Apr 7;48(7):2336-45. doi: 10.1021/jm049146p. J Med Chem. 2005. PMID: 15801827

6

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.

Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Ioanoviciu A, et al. J Med Chem. 2005 Jul 28;48(15):4803-14. doi: 10.1021/jm050076b. J Med Chem. 2005. PMID: 16033260

7

The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).

Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart L. Gerdts CJ, et al. Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1116-22. doi: 10.1107/S0907444908028060. Epub 2008 Oct 18. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 19020349 Free PMC article.

8

The Seattle Structural Genomics Center for Infectious Disease (SSGCID).

Myler PJ, Stacy R, Stewart L, Staker BL, Van Voorhis WC, Varani G, Buchko GW. Myler PJ, et al. Infect Disord Drug Targets. 2009 Nov;9(5):493-506. doi: 10.2174/187152609789105687. Infect Disord Drug Targets. 2009. PMID: 19594426 Free PMC article. Review.

9

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ. Davies DR, et al. Among authors: stewart lj. J Med Chem. 2009 Aug 13;52(15):4694-715. doi: 10.1021/jm900259h. J Med Chem. 2009. PMID: 19618939 Free PMC article.

10

The role of medical structural genomics in discovering new drugs for infectious diseases.

Van Voorhis WC, Hol WG, Myler PJ, Stewart LJ. Van Voorhis WC, et al. Among authors: stewart lj. PLoS Comput Biol. 2009 Oct;5(10):e1000530. doi: 10.1371/journal.pcbi.1000530. Epub 2009 Oct 26. PLoS Comput Biol. 2009. PMID: 19855826 Free PMC article. Review. No abstract available.

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