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Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes.
Satoh T, Rezaie T, Seki M, Sunico CR, Tabuchi T, Kitagawa T, Yanagitai M, Senzaki M, Kosegawa C, Taira H, McKercher SR, Hoffman JK, Roth GP, Lipton SA. Satoh T, et al. Among authors: lipton sa. J Neurochem. 2011 Nov;119(3):569-78. doi: 10.1111/j.1471-4159.2011.07449.x. Epub 2011 Sep 21. J Neurochem. 2011. PMID: 21883218 Free PMC article.
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.
Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Satoh T, et al. Among authors: lipton sa. J Neurochem. 2008 Feb;104(4):1116-31. doi: 10.1111/j.1471-4159.2007.05039.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17995931 Free PMC article.
Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration.
Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S, Tozawa T, Satoh T, Lipton SA. Rezaie T, et al. Among authors: lipton sa. Invest Ophthalmol Vis Sci. 2012 Nov 27;53(12):7847-54. doi: 10.1167/iovs.12-10793. Invest Ophthalmol Vis Sci. 2012. PMID: 23081978 Free PMC article.
478 results