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A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.
Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. Thorne CA, et al. Among authors: lee la, lee e. J Biomol Screen. 2011 Oct;16(9):995-1006. doi: 10.1177/1087057111416657. Epub 2011 Aug 21. J Biomol Screen. 2011. PMID: 21859680 Free PMC article.
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E. Thorne CA, et al. Among authors: lee la, lee e. Nat Chem Biol. 2010 Nov;6(11):829-36. doi: 10.1038/nchembio.453. Epub 2010 Oct 3. Nat Chem Biol. 2010. PMID: 20890287 Free PMC article.
Lrp6 is required for convergent extension during Xenopus gastrulation.
Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. Tahinci E, et al. Among authors: lee la, lee e. Development. 2007 Nov;134(22):4095-106. doi: 10.1242/dev.010272. Development. 2007. PMID: 17965054 Free PMC article.
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. Hanson AJ, et al. Among authors: lee la, lee e. Mol Cell. 2012 Mar 9;45(5):619-28. doi: 10.1016/j.molcel.2011.12.032. Epub 2012 Feb 1. Mol Cell. 2012. PMID: 22304967 Free PMC article.
Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.
Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Broadus MR, et al. Among authors: lee la, lee e. Cell Rep. 2016 May 31;15(9):1920-9. doi: 10.1016/j.celrep.2016.04.070. Epub 2016 May 19. Cell Rep. 2016. PMID: 27210761 Free PMC article.
APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E. Saito-Diaz K, et al. Among authors: lee la, lee e. Dev Cell. 2018 Mar 12;44(5):566-581.e8. doi: 10.1016/j.devcel.2018.02.013. Dev Cell. 2018. PMID: 29533772 Free PMC article.
603 results