Leach MO - Search Results

1

Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents.

Beloueche-Babari M, Workman P, Leach MO. Beloueche-Babari M, et al. Among authors: leach mo. Cell Cycle. 2011 Sep 1;10(17):2883-93. doi: 10.4161/cc.10.17.17192. Epub 2011 Sep 1. Cell Cycle. 2011. PMID: 21857160 Review.

2

Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.

Chung YL, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P, Ronen SM. Chung YL, et al. Among authors: leach mo. J Natl Cancer Inst. 2003 Nov 5;95(21):1624-33. doi: 10.1093/jnci/djg084. J Natl Cancer Inst. 2003. PMID: 14600095

3

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Seddon BM, Payne GS, Simmons L, Ruddle R, Grimshaw R, Tan S, Turner A, Raynaud F, Halbert G, Leach MO, Judson I, Workman P. Seddon BM, et al. Among authors: leach mo. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. Clin Cancer Res. 2003. PMID: 14613987 Review.

4

Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Cancer Res. 2005 Apr 15;65(8):3356-63. doi: 10.1158/10.1158/0008-5472.CAN-03-2981. Cancer Res. 2005. PMID: 15833869

5

A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points.

O'Donnell A, Padhani A, Hayes C, Kakkar AJ, Leach M, Trigo JM, Scurr M, Raynaud F, Phillips S, Aherne W, Hardcastle A, Workman P, Hannah A, Judson I. O'Donnell A, et al. Br J Cancer. 2005 Oct 17;93(8):876-83. doi: 10.1038/sj.bjc.6602797. Br J Cancer. 2005. PMID: 16222321 Free PMC article. Clinical Trial.

6

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Al-Saffar NM, et al. Among authors: leach mo. Cancer Res. 2006 Jan 1;66(1):427-34. doi: 10.1158/0008-5472.CAN-05-1338. Cancer Res. 2006. PMID: 16397258

7

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Eccles SA, Raynaud FI, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Mol Cancer Ther. 2006 Jan;5(1):187-96. doi: 10.1158/1535-7163.MCT-03-0220. Mol Cancer Ther. 2006. PMID: 16432178

8

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies.

Workman P, Aboagye EO, Chung YL, Griffiths JR, Hart R, Leach MO, Maxwell RJ, McSheehy PM, Price PM, Zweit J; Cancer Research UK Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee. Workman P, et al. Among authors: leach mo. J Natl Cancer Inst. 2006 May 3;98(9):580-98. doi: 10.1093/jnci/djj162. J Natl Cancer Inst. 2006. PMID: 16670384 Review.

9

Therapeutic target metabolism observed using hyperpolarized 15N choline.

Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO, Eykyn TR. Gabellieri C, et al. Among authors: leach mo. J Am Chem Soc. 2008 Apr 9;130(14):4598-9. doi: 10.1021/ja8001293. Epub 2008 Mar 18. J Am Chem Soc. 2008. PMID: 18345678

10

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

Chung YL, Troy H, Kristeleit R, Aherne W, Jackson LE, Atadja P, Griffiths JR, Judson IR, Workman P, Leach MO, Beloueche-Babari M. Chung YL, et al. Among authors: leach mo. Neoplasia. 2008 Apr;10(4):303-13. doi: 10.1593/neo.07834. Neoplasia. 2008. PMID: 18392140 Free PMC article.

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