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Aggregation, stability, and formulation of human antibody therapeutics.
Lowe D, Dudgeon K, Rouet R, Schofield P, Jermutus L, Christ D. Lowe D, et al. Among authors: jermutus l. Adv Protein Chem Struct Biol. 2011;84:41-61. doi: 10.1016/B978-0-12-386483-3.00004-5. Adv Protein Chem Struct Biol. 2011. PMID: 21846562 Review.
Expression of high-affinity human antibody fragments in bacteria.
Rouet R, Lowe D, Dudgeon K, Roome B, Schofield P, Langley D, Andrews J, Whitfeld P, Jermutus L, Christ D. Rouet R, et al. Among authors: jermutus l. Nat Protoc. 2012 Feb 2;7(2):364-73. doi: 10.1038/nprot.2011.448. Nat Protoc. 2012. PMID: 22301775
Challenges and opportunities for non-antibody scaffold drugs.
Vazquez-Lombardi R, Phan TG, Zimmermann C, Lowe D, Jermutus L, Christ D. Vazquez-Lombardi R, et al. Among authors: jermutus l. Drug Discov Today. 2015 Oct;20(10):1271-83. doi: 10.1016/j.drudis.2015.09.004. Epub 2015 Sep 7. Drug Discov Today. 2015. PMID: 26360055 Free article. Review.
Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
Ravn P, Madhurantakam C, Kunze S, Matthews E, Priest C, O'Brien S, Collinson A, Papworth M, Fritsch-Fredin M, Jermutus L, Benthem L, Gruetter M, Jackson RH. Ravn P, et al. Among authors: jermutus l. J Biol Chem. 2013 Jul 5;288(27):19760-72. doi: 10.1074/jbc.M112.426288. Epub 2013 May 20. J Biol Chem. 2013. PMID: 23689510 Free PMC article.
Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13.
Urbach C, Gordon NC, Strickland I, Lowne D, Joberty-Candotti C, May R, Herath A, Hijnen D, Thijs JL, Bruijnzeel-Koomen CA, Minter RR, Hollfelder F, Jermutus L. Urbach C, et al. Among authors: jermutus l. Chem Biol. 2015 Nov 19;22(11):1442-1452. doi: 10.1016/j.chembiol.2015.09.013. Epub 2015 Nov 5. Chem Biol. 2015. PMID: 26548614
Improved drug-like properties of therapeutic proteins by directed evolution.
Buchanan A, Ferraro F, Rust S, Sridharan S, Franks R, Dean G, McCourt M, Jermutus L, Minter R. Buchanan A, et al. Among authors: jermutus l. Protein Eng Des Sel. 2012 Oct;25(10):631-8. doi: 10.1093/protein/gzs054. Epub 2012 Aug 31. Protein Eng Des Sel. 2012. PMID: 22942395 Free PMC article.
83 results