Liu L - Search Results

1

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ. Chen Y, et al. Among authors: liu l. Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11. Drug Metab Dispos. 2011. PMID: 21835977

2

Revisiting the metabolism of ketoconazole using accurate mass.

Fitch WL, Tran T, Young M, Liu L, Chen Y. Fitch WL, et al. Among authors: liu l. Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085. Drug Metab Lett. 2009. PMID: 19799546

3

Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.

Fitch WL, Chen Y, Liu L, Paehler A, Young M. Fitch WL, et al. Among authors: liu l. Drug Metab Lett. 2010 Apr;4(2):77-87. doi: 10.2174/187231210791292753. Drug Metab Lett. 2010. PMID: 20446913

4

The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ. Chen Y, et al. Among authors: liu l, liu hf. Xenobiotica. 2010 Aug;40(8):536-46. doi: 10.3109/00498254.2010.492880. Xenobiotica. 2010. PMID: 20528624

5

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

Chen Y, Liu L, Nguyen K, Fretland AJ. Chen Y, et al. Among authors: liu l. Drug Metab Dispos. 2011 Mar;39(3):373-82. doi: 10.1124/dmd.110.035147. Epub 2010 Dec 8. Drug Metab Dispos. 2011. PMID: 21148079

6

Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

Wen B, Roongta V, Liu L, Moore DJ. Wen B, et al. Among authors: liu l. Drug Metab Dispos. 2014 Jun;42(6):1044-54. doi: 10.1124/dmd.114.057414. Epub 2014 Apr 2. Drug Metab Dispos. 2014. PMID: 24696463

7

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.

Chang JH, Chen J, Liu L, Messick K, Ly J. Chang JH, et al. Among authors: liu l. Drug Metab Dispos. 2016 Nov;44(11):1736-1741. doi: 10.1124/dmd.116.072132. Epub 2016 Aug 18. Drug Metab Dispos. 2016. PMID: 27538915

8

Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.

Ly JQ, Wong S, Liu L, Li R, Messick K, Chang JH. Ly JQ, et al. Among authors: liu l. Drug Metab Dispos. 2021 Jul;49(7):540-547. doi: 10.1124/dmd.121.000439. Epub 2021 Apr 16. Drug Metab Dispos. 2021. PMID: 33863817

9

Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.

Bowman CM, Chen B, Cheong J, Liu L, Chen Y, Mao J. Bowman CM, et al. Among authors: liu l. Drug Metab Dispos. 2021 Jul;49(7):530-539. doi: 10.1124/dmd.120.000315. Epub 2021 May 6. Drug Metab Dispos. 2021. PMID: 33958385

10

Evaluation of bottom-up modeling of the blood-brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling.

Bowman C, Ma F, Mao J, Plise E, Chen E, Liu L, Zhang S, Chen Y. Bowman C, et al. Among authors: liu l. Biopharm Drug Dispos. 2023 Feb;44(1):60-70. doi: 10.1002/bdd.2344. Epub 2023 Feb 7. Biopharm Drug Dispos. 2023. PMID: 36630933

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