Chen Y - Search Results

1

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ. Chen Y, et al. Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11. Drug Metab Dispos. 2011. PMID: 21835977

2

Analytical tools and approaches for metabolite identification in early drug discovery.

Chen Y, Monshouwer M, Fitch WL. Chen Y, et al. Pharm Res. 2007 Feb;24(2):248-57. doi: 10.1007/s11095-006-9162-7. Epub 2006 Oct 18. Pharm Res. 2007. PMID: 17048114 Review.

3

Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

Wen B, Chen Y, Fitch WL. Wen B, et al. Among authors: chen y. Drug Metab Dispos. 2009 Jul;37(7):1557-62. doi: 10.1124/dmd.108.024851. Epub 2009 Apr 13. Drug Metab Dispos. 2009. PMID: 19364830

4

Revisiting the metabolism of ketoconazole using accurate mass.

Fitch WL, Tran T, Young M, Liu L, Chen Y. Fitch WL, et al. Among authors: chen y. Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085. Drug Metab Lett. 2009. PMID: 19799546

5

Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.

Fitch WL, Chen Y, Liu L, Paehler A, Young M. Fitch WL, et al. Among authors: chen y. Drug Metab Lett. 2010 Apr;4(2):77-87. doi: 10.2174/187231210791292753. Drug Metab Lett. 2010. PMID: 20446913

6

The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ. Chen Y, et al. Xenobiotica. 2010 Aug;40(8):536-46. doi: 10.3109/00498254.2010.492880. Xenobiotica. 2010. PMID: 20528624

7

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

Chen Y, Liu L, Nguyen K, Fretland AJ. Chen Y, et al. Drug Metab Dispos. 2011 Mar;39(3):373-82. doi: 10.1124/dmd.110.035147. Epub 2010 Dec 8. Drug Metab Dispos. 2011. PMID: 21148079

8

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.

Chen Y, Jin JY, Mukadam S, Malhi V, Kenny JR. Chen Y, et al. Biopharm Drug Dispos. 2012 Mar;33(2):85-98. doi: 10.1002/bdd.1769. Epub 2012 Jan 24. Biopharm Drug Dispos. 2012. PMID: 22228214

9

Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.

Chen Y, Mao J, Hop CE. Chen Y, et al. Drug Metab Dispos. 2015 Feb;43(2):182-9. doi: 10.1124/dmd.114.059311. Epub 2014 Oct 16. Drug Metab Dispos. 2015. PMID: 25324279 Clinical Trial.

10

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.

Mao J, Tay S, Khojasteh CS, Chen Y, Hop CE, Kenny JR. Mao J, et al. Among authors: chen y. Pharm Res. 2016 May;33(5):1204-19. doi: 10.1007/s11095-016-1865-9. Epub 2016 Feb 11. Pharm Res. 2016. PMID: 26869174

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