Chuang HC - Search Results

1

Identification and characterization of a novel integrin-linked kinase inhibitor.

Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. Lee SL, et al. Among authors: chuang hc. J Med Chem. 2011 Sep 22;54(18):6364-74. doi: 10.1021/jm2007744. Epub 2011 Aug 24. J Med Chem. 2011. PMID: 21823616 Free PMC article.

2

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells.

Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS. Wei S, et al. Among authors: chuang hc. J Biol Chem. 2008 Sep 26;283(39):26759-70. doi: 10.1074/jbc.M802160200. Epub 2008 Jul 23. J Biol Chem. 2008. PMID: 18650423 Free PMC article.

3

alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion.

Wang D, Chuang HC, Weng SC, Huang PH, Hsieh HY, Kulp SK, Chen CS. Wang D, et al. Among authors: chuang hc. J Med Chem. 2009 Sep 24;52(18):5642-8. doi: 10.1021/jm9002457. J Med Chem. 2009. PMID: 19708661 Free PMC article.

4

The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition.

Chu PC, Chuang HC, Kulp SK, Chen CS. Chu PC, et al. Among authors: chuang hc. J Biol Chem. 2012 Dec 21;287(52):43639-50. doi: 10.1074/jbc.M112.393678. Epub 2012 Oct 31. J Biol Chem. 2012. PMID: 23115237 Free PMC article.

5

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.

Huang PH, Chuang HC, Chou CC, Wang H, Lee SL, Yang HC, Chiu HC, Kapuriya N, Wang D, Kulp SK, Chen CS. Huang PH, et al. Among authors: chuang hc. Sci Signal. 2013 Mar 19;6(267):ra19. doi: 10.1126/scisignal.2003816. Sci Signal. 2013. PMID: 23512990 Free PMC article.

6

Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.

Lee SL, Chou CC, Chuang HC, Hsu EC, Chiu PC, Kulp SK, Byrd JC, Chen CS. Lee SL, et al. Among authors: chuang hc. PLoS One. 2013 Jun 19;8(6):e67149. doi: 10.1371/journal.pone.0067149. Print 2013. PLoS One. 2013. Retraction in: PLoS One. 2018 Aug 9;13(8):e0202299. doi: 10.1371/journal.pone.0202299 PMID: 23840605 Free PMC article. Retracted.

7

Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.

Yan R, Chuang HC, Kapuriya N, Chou CC, Lai PT, Chang HW, Yang CN, Kulp SK, Chen CS. Yan R, et al. Among authors: chuang hc. J Med Chem. 2015 Mar 12;58(5):2290-8. doi: 10.1021/jm501751b. Epub 2015 Feb 27. J Med Chem. 2015. PMID: 25689347 Free PMC article.

8

Targeting breast cancer stem cells by novel HDAC3-selective inhibitors.

Hsieh HY, Chuang HC, Shen FH, Detroja K, Hsin LW, Chen CS. Hsieh HY, et al. Among authors: chuang hc. Eur J Med Chem. 2017 Nov 10;140:42-51. doi: 10.1016/j.ejmech.2017.08.069. Epub 2017 Sep 1. Eur J Med Chem. 2017. PMID: 28923385

9

Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein.

Wei S, Chuang HC, Tsai WC, Yang HC, Ho SR, Paterson AJ, Kulp SK, Chen CS. Wei S, et al. Among authors: chuang hc. Mol Pharmacol. 2009 Jul;76(1):47-57. doi: 10.1124/mol.109.055376. Epub 2009 Apr 16. Mol Pharmacol. 2009. PMID: 19372209 Free PMC article.

10

alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis.

Huang PH, Wang D, Chuang HC, Wei S, Kulp SK, Chen CS. Huang PH, et al. Among authors: chuang hc. Carcinogenesis. 2009 Jul;30(7):1125-31. doi: 10.1093/carcin/bgp112. Epub 2009 May 6. Carcinogenesis. 2009. PMID: 19420015 Free PMC article.

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