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Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B.
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, Facchini A, Flamigni F, Santi S, Facchini A, Borzi' RM. Olivotto E, et al. J Cell Physiol. 2007 Feb;210(2):417-27. doi: 10.1002/jcp.20864. J Cell Physiol. 2007. PMID: 17096385
Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors.
Borzí RM, Olivotto E, Pagani S, Vitellozzi R, Neri S, Battistelli M, Falcieri E, Facchini A, Flamigni F, Penzo M, Platano D, Santi S, Facchini A, Marcu KB. Borzí RM, et al. Among authors: olivotto e. Arthritis Rheum. 2010 Aug;62(8):2370-81. doi: 10.1002/art.27512. Arthritis Rheum. 2010. PMID: 20506238 Free PMC article.
A role for chemokines in the induction of chondrocyte phenotype modulation.
Mazzetti I, Magagnoli G, Paoletti S, Uguccioni M, Olivotto E, Vitellozzi R, Cattini L, Facchini A, Borzì RM. Mazzetti I, et al. Among authors: olivotto e. Arthritis Rheum. 2004 Jan;50(1):112-22. doi: 10.1002/art.11474. Arthritis Rheum. 2004. PMID: 14730607 Free article.
Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro.
Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzì RM, Meliconi R. Assirelli E, et al. Among authors: olivotto e. PLoS One. 2014 May 12;9(5):e96925. doi: 10.1371/journal.pone.0096925. eCollection 2014. PLoS One. 2014. PMID: 24819779 Free PMC article.
42 results