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Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.
Anwar A, Li M, Frid MG, Kumar B, Gerasimovskaya EV, Riddle SR, McKeon BA, Thukaram R, Meyrick BO, Fini MA, Stenmark KR. Anwar A, et al. Among authors: li m. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L1-L11. doi: 10.1152/ajplung.00050.2012. Epub 2012 May 11. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22582113 Free PMC article.
Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.
El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. El Kasmi KC, et al. Among authors: li m. J Immunol. 2014 Jul 15;193(2):597-609. doi: 10.4049/jimmunol.1303048. Epub 2014 Jun 13. J Immunol. 2014. PMID: 24928992 Free PMC article.
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.
Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldovan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Caánovas A, Medrano JF, Thomas MG, Iloska D, Plecitá-Hlavatá L, Ježek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Li M, et al. Among authors: li h. Circulation. 2016 Oct 11;134(15):1105-1121. doi: 10.1161/CIRCULATIONAHA.116.023171. Epub 2016 Aug 25. Circulation. 2016. PMID: 27562971 Free PMC article.
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
Frid MG, Li M, Gnanasekharan M, Burke DL, Fragoso M, Strassheim D, Sylman JL, Stenmark KR. Frid MG, et al. Among authors: li m. Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1059-72. doi: 10.1152/ajplung.90611.2008. Epub 2009 Sep 18. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19767409 Free PMC article.
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Cavasin MA, et al. Among authors: li m. Circ Res. 2012 Mar 2;110(5):739-48. doi: 10.1161/CIRCRESAHA.111.258426. Epub 2012 Jan 26. Circ Res. 2012. PMID: 22282194 Free PMC article.
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