Fridell RA - Search Results

1

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

Fridell RA, Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M. Fridell RA, et al. Hepatology. 2011 Dec;54(6):1924-35. doi: 10.1002/hep.24594. Hepatology. 2011. PMID: 21809362 Clinical Trial.

2

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.

Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, Grasela DM, Meanwell NA, Hamann LG. Gao M, et al. Among authors: fridell ra. Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960. Epub 2010 Apr 21. Nature. 2010. PMID: 20410884 Free PMC article. Clinical Trial.

3

Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system.

Fridell RA, Qiu D, Wang C, Valera L, Gao M. Fridell RA, et al. Antimicrob Agents Chemother. 2010 Sep;54(9):3641-50. doi: 10.1128/AAC.00556-10. Epub 2010 Jun 28. Antimicrob Agents Chemother. 2010. PMID: 20585111 Free PMC article.

4

Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052.

Fridell RA, Qiu D, Valera L, Wang C, Rose RE, Gao M. Fridell RA, et al. J Virol. 2011 Jul;85(14):7312-20. doi: 10.1128/JVI.00253-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593143 Free PMC article.

5

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

Qiu D, Lemm JA, O'Boyle DR, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA. Qiu D, et al. Among authors: fridell ra. J Gen Virol. 2011 Nov;92(Pt 11):2502-2511. doi: 10.1099/vir.0.034801-0. Epub 2011 Jul 27. J Gen Virol. 2011. PMID: 21795470

6

In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.

Wang C, Jia L, Huang H, Qiu D, Valera L, Huang X, Sun JH, Nower PT, O'Boyle DR 2nd, Gao M, Fridell RA. Wang C, et al. Among authors: fridell ra. Antimicrob Agents Chemother. 2012 Mar;56(3):1588-90. doi: 10.1128/AAC.06169-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203595 Free PMC article.

7

Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.

Wang C, Huang H, Valera L, Sun JH, O'Boyle DR 2nd, Nower PT, Jia L, Qiu D, Huang X, Altaf A, Gao M, Fridell RA. Wang C, et al. Among authors: fridell ra. Antimicrob Agents Chemother. 2012 Mar;56(3):1350-8. doi: 10.1128/AAC.05977-11. Epub 2012 Jan 3. Antimicrob Agents Chemother. 2012. PMID: 22214777 Free PMC article.

8

Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052.

Sun JH, O'Boyle Ii DR, Zhang Y, Wang C, Nower P, Valera L, Roberts S, Nettles RE, Fridell RA, Gao M. Sun JH, et al. Among authors: fridell ra. Hepatology. 2012 Jun;55(6):1692-9. doi: 10.1002/hep.25581. Hepatology. 2012. PMID: 22234905

9

In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.

Wang C, Valera L, Jia L, Kirk MJ, Gao M, Fridell RA. Wang C, et al. Among authors: fridell ra. Antimicrob Agents Chemother. 2013 Jan;57(1):611-3. doi: 10.1128/AAC.01874-12. Epub 2012 Oct 22. Antimicrob Agents Chemother. 2013. PMID: 23089758 Free PMC article.

10

Intragenic complementation of hepatitis C virus NS5A RNA replication-defective alleles.

Fridell RA, Valera L, Qiu D, Kirk MJ, Wang C, Gao M. Fridell RA, et al. J Virol. 2013 Feb;87(4):2320-9. doi: 10.1128/JVI.02861-12. Epub 2012 Dec 12. J Virol. 2013. PMID: 23236071 Free PMC article.

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