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Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.
Wüller S, Wiesner B, Löffler A, Furkert J, Krause G, Hermosilla R, Schaefer M, Schülein R, Rosenthal W, Oksche A. Wüller S, et al. Among authors: schulein r. J Biol Chem. 2004 Nov 5;279(45):47254-63. doi: 10.1074/jbc.M408154200. Epub 2004 Aug 19. J Biol Chem. 2004. PMID: 15319430 Free article.
The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz K, Rutz C, Westendorf C, Ridelis I, Vogelbein S, Furkert J, Schmidt A, Wiesner B, Schülein R. Schulz K, et al. Among authors: schulein r. J Biol Chem. 2010 Oct 22;285(43):32878-32887. doi: 10.1074/jbc.M110.129627. Epub 2010 Aug 3. J Biol Chem. 2010. PMID: 20682782 Free PMC article.
From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).
Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R. Kleinau G, et al. Among authors: schulein r. J Biol Chem. 2011 Jul 22;286(29):25859-71. doi: 10.1074/jbc.M110.196980. Epub 2011 May 17. J Biol Chem. 2011. PMID: 21586576 Free PMC article.
81 results