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The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.
Daliry A, Pires MQ, Silva CF, Pacheco RS, Munde M, Stephens CE, Kumar A, Ismail MA, Liu Z, Farahat AA, Akay S, Som P, Hu Q, Boykin DW, Wilson WD, De Castro SL, Soeiro MN. Daliry A, et al. Among authors: kumar a. Antimicrob Agents Chemother. 2011 Oct;55(10):4765-73. doi: 10.1128/AAC.00229-11. Epub 2011 Aug 1. Antimicrob Agents Chemother. 2011. PMID: 21807972 Free PMC article.
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi.
De Araújo JS, Da Silva CF, Batista DG, Da Silva PB, Meuser MB, Aiub CA, da Silva MF, Araújo-Lima CF, Banerjee M, Farahat AA, Stephens CE, Kumar A, Boykin DW, Soeiro MN. De Araújo JS, et al. Among authors: kumar a. Antimicrob Agents Chemother. 2014 Jul;58(7):4191-5. doi: 10.1128/AAC.01403-13. Epub 2014 Mar 3. Antimicrob Agents Chemother. 2014. PMID: 24590476 Free PMC article.
Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi.
Simões-Silva MR, Nefertiti AS, De Araújo JS, Batista MM, Da Silva PB, Bahia MT, Menna-Barreto RS, Pavão BP, Green J, Farahat AA, Kumar A, Boykin DW, Soeiro MN. Simões-Silva MR, et al. Among authors: kumar a. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4701-7. doi: 10.1128/AAC.01788-15. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27216059 Free PMC article.
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