Filippakopoulos P - Search Results

1

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Miduturu CV, et al. Among authors: filippakopoulos p. Chem Biol. 2011 Jul 29;18(7):868-79. doi: 10.1016/j.chembiol.2011.05.010. Chem Biol. 2011. PMID: 21802008 Free PMC article.

2

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Kwiatkowski N, et al. Among authors: filippakopoulos p. Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11. Nat Chem Biol. 2010. PMID: 20383151 Free PMC article.

3

Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.

Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE. Hellwig S, et al. Among authors: filippakopoulos p. Chem Biol. 2012 Apr 20;19(4):529-40. doi: 10.1016/j.chembiol.2012.01.020. Chem Biol. 2012. PMID: 22520759 Free PMC article.

4

7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.

Huber K, Brault L, Fedorov O, Gasser C, Filippakopoulos P, Bullock AN, Fabbro D, Trappe J, Schwaller J, Knapp S, Bracher F. Huber K, et al. Among authors: filippakopoulos p. J Med Chem. 2012 Jan 12;55(1):403-13. doi: 10.1021/jm201286z. Epub 2012 Jan 3. J Med Chem. 2012. PMID: 22136433 Free PMC article.

5

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.

Pogacic V, Bullock AN, Fedorov O, Filippakopoulos P, Gasser C, Biondi A, Meyer-Monard S, Knapp S, Schwaller J. Pogacic V, et al. Among authors: filippakopoulos p. Cancer Res. 2007 Jul 15;67(14):6916-24. doi: 10.1158/0008-5472.CAN-07-0320. Cancer Res. 2007. PMID: 17638903

6

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.

Akué-Gédu R, Rossignol E, Azzaro S, Knapp S, Filippakopoulos P, Bullock AN, Bain J, Cohen P, Prudhomme M, Anizon F, Moreau P. Akué-Gédu R, et al. Among authors: filippakopoulos p. J Med Chem. 2009 Oct 22;52(20):6369-81. doi: 10.1021/jm901018f. J Med Chem. 2009. PMID: 19788246

7

SH2 domains: modulators of nonreceptor tyrosine kinase activity.

Filippakopoulos P, Müller S, Knapp S. Filippakopoulos P, et al. Curr Opin Struct Biol. 2009 Dec;19(6):643-9. doi: 10.1016/j.sbi.2009.10.001. Epub 2009 Nov 18. Curr Opin Struct Biol. 2009. PMID: 19926274 Free PMC article. Review.

8

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, Szklarczyk D, Jensen LJ, Fabbro D, Trappe J, Rauch U, Bracher F, Knapp S. Fedorov O, et al. Among authors: filippakopoulos p. Chem Biol. 2011 Jan 28;18(1):67-76. doi: 10.1016/j.chembiol.2010.11.009. Chem Biol. 2011. PMID: 21276940 Free PMC article.

9

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.

Ciceri P, Müller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S. Ciceri P, et al. Among authors: filippakopoulos p. Nat Chem Biol. 2014 Apr;10(4):305-12. doi: 10.1038/nchembio.1471. Epub 2014 Mar 2. Nat Chem Biol. 2014. PMID: 24584101 Free PMC article.

10

Targeting bromodomains: epigenetic readers of lysine acetylation.

Filippakopoulos P, Knapp S. Filippakopoulos P, et al. Nat Rev Drug Discov. 2014 May;13(5):337-56. doi: 10.1038/nrd4286. Epub 2014 Apr 22. Nat Rev Drug Discov. 2014. PMID: 24751816 Review.

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