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Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PLoS One. 2011;6(7):e22489. doi: 10.1371/journal.pone.0022489. Epub 2011 Jul 22.
PLoS One. 2011.
PMID: 21799870
Free PMC article.
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine MJ, Zerle J, Kara E, Taanman JW, Healy DG, Marti-Masso JF, Schapira AH, Plun-Favreau H, Tooze S, Hardy J, Bandopadhyay R, Lewis PA.
Manzoni C, et al. Among authors: zerle j.
Biochem Biophys Res Commun. 2013 Nov 29;441(4):862-6. doi: 10.1016/j.bbrc.2013.10.159. Epub 2013 Nov 6.
Biochem Biophys Res Commun. 2013.
PMID: 24211199
Free PMC article.
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Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
Giesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, Ernst L, Zhang J, Vogt-Weisenhorn DM, Wurst W.
Giesert F, et al. Among authors: zerle j.
PLoS One. 2013 May 10;8(5):e63778. doi: 10.1371/journal.pone.0063778. Print 2013.
PLoS One. 2013.
PMID: 23675505
Free PMC article.
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The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Giesert F, Glasl L, Zimprich A, Ernst L, Piccoli G, Stautner C, Zerle J, Hölter SM, Vogt Weisenhorn DM, Wurst W.
Giesert F, et al. Among authors: zerle j.
Neurobiol Dis. 2017 Sep;105:179-193. doi: 10.1016/j.nbd.2017.05.013. Epub 2017 May 31.
Neurobiol Dis. 2017.
PMID: 28576705
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Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
Glasl L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zhang J, Hafen U, Zerle J, Hofmann A, de Angelis MH, Winklhofer KF, Hölter SM, Vogt Weisenhorn DM, Wurst W.
Glasl L, et al. Among authors: zerle j.
Exp Neurol. 2012 May;235(1):214-27. doi: 10.1016/j.expneurol.2012.01.002. Epub 2012 Jan 11.
Exp Neurol. 2012.
PMID: 22265660
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