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The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.
Roher AE, Kokjohn TA, Esh C, Weiss N, Childress J, Kalback W, Luehrs DC, Lopez J, Brune D, Kuo YM, Farlow M, Murrell J, Vidal R, Ghetti B. Roher AE, et al. Among authors: kokjohn ta. J Biol Chem. 2004 Feb 13;279(7):5829-36. doi: 10.1074/jbc.M311380200. Epub 2003 Nov 26. J Biol Chem. 2004. PMID: 14645225 Free article.
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Van Vickle GD, Esh CL, Kalback WM, Patton RL, Luehrs DC, Kokjohn TA, Fifield FG, Fraser PE, Westaway D, McLaurin J, Lopez J, Brune D, Newel AJ, Poston M, Beach TG, Roher AE. Van Vickle GD, et al. Among authors: kokjohn ta. Biochemistry. 2007 Sep 11;46(36):10317-27. doi: 10.1021/bi700951u. Epub 2007 Aug 18. Biochemistry. 2007. PMID: 17705508
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Van Vickle GD, Esh CL, Daugs ID, Kokjohn TA, Kalback WM, Patton RL, Luehrs DC, Walker DG, Lue LF, Beach TG, Davis J, Van Nostrand WE, Castaño EM, Roher AE. Van Vickle GD, et al. Among authors: kokjohn ta. Am J Pathol. 2008 Aug;173(2):483-93. doi: 10.2353/ajpath.2008.071191. Epub 2008 Jul 3. Am J Pathol. 2008. PMID: 18599612 Free PMC article.
Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease.
Roher AE, Esh CL, Kokjohn TA, Castaño EM, Van Vickle GD, Kalback WM, Patton RL, Luehrs DC, Daugs ID, Kuo YM, Emmerling MR, Soares H, Quinn JF, Kaye J, Connor DJ, Silverberg NB, Adler CH, Seward JD, Beach TG, Sabbagh MN. Roher AE, et al. Among authors: kokjohn ta. Alzheimers Dement. 2009 Jan;5(1):18-29. doi: 10.1016/j.jalz.2008.10.004. Alzheimers Dement. 2009. PMID: 19118806 Free PMC article.
74 results