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Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH. Needham LA, et al. Among authors: drummond ah. J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21. J Pharmacol Exp Ther. 2011. PMID: 21778281
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE, Stone E, Callaghan J, Chandler S, Clark VL, Kirwin-Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood LM, Eccles SA, Bone EA, Ayscough A, Drummond AH. Krige D, et al. Among authors: drummond ah. Cancer Res. 2008 Aug 15;68(16):6669-79. doi: 10.1158/0008-5472.CAN-07-6627. Cancer Res. 2008. PMID: 18701491 Free article.
Matrix metalloproteinases and processing of pro-TNF-alpha.
Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements JM, Crimmin M, Davidson AH, Drummond AH, Galloway WA, Gilbert R, et al. Gearing AJ, et al. Among authors: drummond ah. J Leukoc Biol. 1995 May;57(5):774-7. doi: 10.1002/jlb.57.5.774. J Leukoc Biol. 1995. PMID: 7759957 Review.
Aminopeptidase inhibition as a targeted treatment strategy in myeloma.
Moore HE, Davenport EL, Smith EM, Muralikrishnan S, Dunlop AS, Walker BA, Krige D, Drummond AH, Hooftman L, Morgan GJ, Davies FE. Moore HE, et al. Among authors: drummond ah. Mol Cancer Ther. 2009 Apr;8(4):762-70. doi: 10.1158/1535-7163.MCT-08-0735. Mol Cancer Ther. 2009. PMID: 19372548 Free article.
Preclinical and clinical studies of MMP inhibitors in cancer.
Drummond AH, Beckett P, Brown PD, Bone EA, Davidson AH, Galloway WA, Gearing AJ, Huxley P, Laber D, McCourt M, Whittaker M, Wood LM, Wright A. Drummond AH, et al. Ann N Y Acad Sci. 1999 Jun 30;878:228-35. doi: 10.1111/j.1749-6632.1999.tb07688.x. Ann N Y Acad Sci. 1999. PMID: 10415734 Review.
Processing of tumour necrosis factor-alpha precursor by metalloproteinases.
Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, et al. Gearing AJ, et al. Among authors: drummond ah. Nature. 1994 Aug 18;370(6490):555-7. doi: 10.1038/370555a0. Nature. 1994. PMID: 8052310
The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.
Pratt LM, Beckett RP, Bellamy CL, Corkill DJ, Cossins J, Courtney PF, Davies SJ, Davidson AH, Drummond AH, Helfrich K, Lewis CN, Mangan M, Martin FM, Miller K, Nayee P, Ricketts ML, Thomas W, Todd RS, Whittaker M. Pratt LM, et al. Among authors: drummond ah. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1359-64. doi: 10.1016/s0960-894x(98)00218-2. Bioorg Med Chem Lett. 1998. PMID: 9871766
61 results