Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII.
Tangelder M, Long C, Emmerechts J, Jacquemin M, Peerlinck K, Vanassche T, Glazer S, Giesen P, Hoylaerts M, Verhamme P.
Tangelder M, et al. Among authors: long c.
J Thromb Haemost. 2012 Jul;10(7):1371-8. doi: 10.1111/j.1538-7836.2012.04762.x.
J Thromb Haemost. 2012.
PMID: 22540161
Free article.
Clinical Trial.
TB-402 concentrations, FVIII activity (FVIII:C), activated partial thromboplastin time (APTT) and thrombin generation were measured over a period of 8 weeks. RESULTS: In spiked samples, TB-402 inhibited FVIII:C by 30%, prolonged APTT by 4.5 s, and reduced the peak h …
TB-402 concentrations, FVIII activity (FVIII:C), activated partial thromboplastin time (APTT) and thrombin generation were measured o …