Lenaerts I - Search Results

1

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.

Andrés JI, De Angelis M, Alcázar J, Iturrino L, Langlois X, Dedeurwaerdere S, Lenaerts I, Vanhoof G, Celen S, Bormans G. Andrés JI, et al. Among authors: lenaerts i. J Med Chem. 2011 Aug 25;54(16):5820-35. doi: 10.1021/jm200536d. Epub 2011 Aug 2. J Med Chem. 2011. PMID: 21777010

2

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Fernández J, Font LM, Hens KA, Iturrino L, Lenaerts I, Martínez S, Megens AA, Pastor J, Vermote PC, Steckler T. Andrés JI, et al. Among authors: lenaerts i. J Med Chem. 2005 Mar 24;48(6):2054-71. doi: 10.1021/jm049619s. J Med Chem. 2005. PMID: 15771448

3

Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.

Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Drinkenburg W, Fernández J, Font LM, Iturrino L, Langlois X, Lenaerts I, Martínez S, Megens AA, Pastor J, Pullan S, Steckler T. Andrés JI, et al. Among authors: lenaerts i. Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. doi: 10.1016/j.bmc.2007.03.053. Epub 2007 Mar 21. Bioorg Med Chem. 2007. PMID: 17407815

4

Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs.

Megens AA, Hendrickx HM, Hens KA, Fonteyn I, Langlois X, Lenaerts I, Somers MV, de Boer P, Vanhoof G. Megens AA, et al. Among authors: lenaerts i. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. doi: 10.1124/jpet.113.211904. Epub 2014 Jan 13. J Pharmacol Exp Ther. 2014. PMID: 24421319

5

Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission.

Ooms M, Celen S, De Hoogt R, Lenaerts I, Liebregts J, Vanhoof G, Langlois X, Postnov A, Koole M, Verbruggen A, Van Laere K, Bormans G. Ooms M, et al. Among authors: lenaerts i. EJNMMI Radiopharm Chem. 2017;1(1):3. doi: 10.1186/s41181-016-0005-5. Epub 2016 Mar 21. EJNMMI Radiopharm Chem. 2017. PMID: 29564380 Free PMC article.

6

Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania.

Prickaerts J, Moechars D, Cryns K, Lenaerts I, van Craenendonck H, Goris I, Daneels G, Bouwknecht JA, Steckler T. Prickaerts J, et al. Among authors: lenaerts i. J Neurosci. 2006 Aug 30;26(35):9022-9. doi: 10.1523/JNEUROSCI.5216-05.2006. J Neurosci. 2006. PMID: 16943560 Free PMC article.

7

Chronic corticosterone manipulations in mice affect brain cell proliferation rates, but only partly affect BDNF protein levels.

Prickaerts J, van den Hove DL, Fierens FL, Kia HK, Lenaerts I, Steckler T. Prickaerts J, et al. Among authors: lenaerts i. Neurosci Lett. 2006 Mar 20;396(1):12-6. doi: 10.1016/j.neulet.2005.11.002. Epub 2005 Dec 2. Neurosci Lett. 2006. PMID: 16326007

8

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

Dhuyvetter D, Tekle F, Nazarov M, Vreeken RJ, Borghys H, Rombouts F, Lenaerts I, Bottelbergs A. Dhuyvetter D, et al. Among authors: lenaerts i. Drug Deliv. 2020 Dec;27(1):1597-1607. doi: 10.1080/10717544.2020.1837291. Drug Deliv. 2020. PMID: 33169635 Free PMC article.

9

Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons.

Dries E, Santiago DJ, Gilbert G, Lenaerts I, Vandenberk B, Nagaraju CK, Johnson DM, Holemans P, Roderick HL, Macquaide N, Claus P, Sipido KR. Dries E, et al. Among authors: lenaerts i. Cardiovasc Res. 2018 Sep 1;114(11):1512-1524. doi: 10.1093/cvr/cvy088. Cardiovasc Res. 2018. PMID: 29668881 Free PMC article.

10

Selective modulation of coupled ryanodine receptors during microdomain activation of calcium/calmodulin-dependent kinase II in the dyadic cleft.

Dries E, Bito V, Lenaerts I, Antoons G, Sipido KR, Macquaide N. Dries E, et al. Among authors: lenaerts i. Circ Res. 2013 Nov 8;113(11):1242-52. doi: 10.1161/CIRCRESAHA.113.301896. Epub 2013 Sep 30. Circ Res. 2013. PMID: 24081880

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