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The PrP-like proteins Shadoo and Doppel.
Westaway D, Daude N, Wohlgemuth S, Harrison P. Westaway D, et al. Top Curr Chem. 2011;305:225-56. doi: 10.1007/128_2011_190. Top Curr Chem. 2011. PMID: 21728138 Review.
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Moore RC, et al. Among authors: westaway d. J Mol Biol. 1999 Oct 1;292(4):797-817. doi: 10.1006/jmbi.1999.3108. J Mol Biol. 1999. PMID: 10525406
Doppel-induced cerebellar degeneration in transgenic mice.
Moore RC, Mastrangelo P, Bouzamondo E, Heinrich C, Legname G, Prusiner SB, Hood L, Westaway D, DeArmond SJ, Tremblay P. Moore RC, et al. Among authors: westaway d. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15288-93. doi: 10.1073/pnas.251550798. Epub 2001 Dec 4. Proc Natl Acad Sci U S A. 2001. PMID: 11734625 Free PMC article.
The PrP-like protein Doppel binds copper.
Qin K, Coomaraswamy J, Mastrangelo P, Yang Y, Lugowski S, Petromilli C, Prusiner SB, Fraser PE, Goldberg JM, Chakrabartty A, Westaway D. Qin K, et al. Among authors: westaway d. J Biol Chem. 2003 Mar 14;278(11):8888-96. doi: 10.1074/jbc.M210875200. Epub 2002 Dec 13. J Biol Chem. 2003. PMID: 12482851 Free article.
Contrary to expectations, Cu(II) induced a 26% reduction in the intrinsic fluorescence of Dpl(27-154) and a calculated K(d) for a single-site model of 0.16 +/- 0.08 microm. Other metals had minimal effects on fluorescence quenching. ...Fluorescence quenching and equilibriu …
Contrary to expectations, Cu(II) induced a 26% reduction in the intrinsic fluorescence of Dpl(27-154) and a calculated K(d) for a sin …
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, Westaway D. Drisaldi B, et al. Among authors: westaway d. J Biol Chem. 2004 Dec 31;279(53):55443-54. doi: 10.1074/jbc.M404794200. Epub 2004 Sep 29. J Biol Chem. 2004. PMID: 15459186 Free article.
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D. Watts JC, et al. Among authors: westaway d. EMBO J. 2007 Sep 5;26(17):4038-50. doi: 10.1038/sj.emboj.7601830. Epub 2007 Aug 16. EMBO J. 2007. PMID: 17703189 Free PMC article.
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