Zamek-Gliszczynski MJ - Search Results

1

Efflux transport is an important determinant of ethinylestradiol glucuronide and ethinylestradiol sulfate pharmacokinetics.

Zamek-Gliszczynski MJ, Day JS, Hillgren KM, Phillips DL. Zamek-Gliszczynski MJ, et al. Drug Metab Dispos. 2011 Oct;39(10):1794-800. doi: 10.1124/dmd.111.040162. Epub 2011 Jun 27. Drug Metab Dispos. 2011. PMID: 21708882

2

Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling.

Zamek-Gliszczynski MJ, Bao JQ, Day JS, Higgins JW. Zamek-Gliszczynski MJ, et al. Drug Metab Dispos. 2013 Nov;41(11):1967-71. doi: 10.1124/dmd.113.053025. Epub 2013 Sep 5. Drug Metab Dispos. 2013. PMID: 24009308

3

Highlights from the International Transporter Consortium second workshop.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. Zamek-Gliszczynski MJ, et al. Clin Pharmacol Ther. 2012 Nov;92(5):553-6. doi: 10.1038/clpt.2012.126. Clin Pharmacol Ther. 2012. PMID: 23085880

4

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW. Zamek-Gliszczynski MJ, et al. Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18. Drug Metab Dispos. 2012. PMID: 22711747

5

Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.

Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP. Zamek-Gliszczynski MJ, et al. Drug Metab Dispos. 2013 Jun;41(6):1174-8. doi: 10.1124/dmd.113.051409. Epub 2013 Apr 8. Drug Metab Dispos. 2013. PMID: 23569176

6

Relationship between drug/metabolite exposure and impairment of excretory transport function.

Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, Brouwer KL. Zamek-Gliszczynski MJ, et al. Drug Metab Dispos. 2009 Feb;37(2):386-90. doi: 10.1124/dmd.108.023648. Epub 2008 Nov 20. Drug Metab Dispos. 2009. PMID: 19022942 Free PMC article.

7

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2012 Jun;40(6):1170-7. doi: 10.1124/dmd.112.044875. Epub 2012 Mar 9. Drug Metab Dispos. 2012. PMID: 22407892

8

Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.

Higgins JW, Ke AB, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2014 Nov;42(11):1780-4. doi: 10.1124/dmd.114.058784. Epub 2014 Aug 8. Drug Metab Dispos. 2014. PMID: 25106415

9

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

Lee CA, O'Connor MA, Ritchie TK, Galetin A, Cook JA, Ragueneau-Majlessi I, Ellens H, Feng B, Taub ME, Paine MF, Polli JW, Ware JA, Zamek-Gliszczynski MJ. Lee CA, et al. Drug Metab Dispos. 2015 Apr;43(4):490-509. doi: 10.1124/dmd.114.062174. Epub 2015 Jan 13. Drug Metab Dispos. 2015. PMID: 25587128 Review.

10

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.

Higgins JW, Bao JQ, Ke AB, Manro JR, Fallon JK, Smith PC, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2014 Jan;42(1):182-92. doi: 10.1124/dmd.113.054783. Epub 2013 Nov 5. Drug Metab Dispos. 2014. PMID: 24194513

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