Brown ED - Search Results

1

Antibiotics as probes of biological complexity.

Falconer SB, Czarny TL, Brown ED. Falconer SB, et al. Among authors: brown ed. Nat Chem Biol. 2011 Jul;7(7):415-23. doi: 10.1038/nchembio.590. Nat Chem Biol. 2011. PMID: 21685879 Review. No abstract available.

2

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.

Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED. Li X, et al. Among authors: brown ed. Chem Biol. 2004 Oct;11(10):1423-30. doi: 10.1016/j.chembiol.2004.08.014. Chem Biol. 2004. PMID: 15489169

3

New targets and screening approaches in antimicrobial drug discovery.

Brown ED, Wright GD. Brown ED, et al. Chem Rev. 2005 Feb;105(2):759-74. doi: 10.1021/cr030116o. Chem Rev. 2005. PMID: 15700964 Review. No abstract available.

4

Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE.

Mangat CS, Brown ED. Mangat CS, et al. Among authors: brown ed. Chem Biol. 2008 Dec 22;15(12):1287-95. doi: 10.1016/j.chembiol.2008.10.007. Chem Biol. 2008. PMID: 19101473

5

New screens and targets in antibacterial drug discovery.

Falconer SB, Brown ED. Falconer SB, et al. Among authors: brown ed. Curr Opin Microbiol. 2009 Oct;12(5):497-504. doi: 10.1016/j.mib.2009.07.001. Epub 2009 Aug 3. Curr Opin Microbiol. 2009. PMID: 19651534 Review.

6

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. Pathania R, et al. Among authors: brown ed. Nat Chem Biol. 2009 Nov;5(11):849-56. doi: 10.1038/nchembio.221. Epub 2009 Sep 27. Nat Chem Biol. 2009. PMID: 19783991

7

Chemical probes of Escherichia coli uncovered through chemical-chemical interaction profiling with compounds of known biological activity.

Farha MA, Brown ED. Farha MA, et al. Among authors: brown ed. Chem Biol. 2010 Aug 27;17(8):852-62. doi: 10.1016/j.chembiol.2010.06.008. Chem Biol. 2010. PMID: 20797614

8

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Ejim L, et al. Among authors: brown ed. Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24. Nat Chem Biol. 2011. PMID: 21516114

9

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

Farha MA, Leung A, Sewell EW, D'Elia MA, Allison SE, Ejim L, Pereira PM, Pinho MG, Wright GD, Brown ED. Farha MA, et al. Among authors: brown ed. ACS Chem Biol. 2013 Jan 18;8(1):226-33. doi: 10.1021/cb300413m. Epub 2012 Oct 19. ACS Chem Biol. 2013. PMID: 23062620 Free PMC article.

10

Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus.

Farha MA, Verschoor CP, Bowdish D, Brown ED. Farha MA, et al. Among authors: brown ed. Chem Biol. 2013 Sep 19;20(9):1168-78. doi: 10.1016/j.chembiol.2013.07.006. Epub 2013 Aug 22. Chem Biol. 2013. PMID: 23972939

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