Paccaly AJ - Search Results

1

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients.

Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. Diacon AH, et al. Among authors: paccaly aj. Int J Tuberc Lung Dis. 2011 Jul;15(7):949-54. doi: 10.5588/ijtld.10.0616. Int J Tuberc Lung Dis. 2011. PMID: 21682970 Clinical Trial.

2

Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects.

Mallikaarjun S, Wells C, Petersen C, Paccaly A, Shoaf SE, Patil S, Geiter L. Mallikaarjun S, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5976-85. doi: 10.1128/AAC.00509-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27458223 Free PMC article. Clinical Trial.

3

Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor.

Paccaly A, Ozoux ML, Chu V, Simcox K, Marks V, Freyburger G, Sibille M, Shukla U. Paccaly A, et al. Thromb Haemost. 2005 Dec;94(6):1156-63. doi: 10.1160/TH05-05-0347. Thromb Haemost. 2005. PMID: 16411387 Clinical Trial.

4

Utilizing physiologically based pharmacokinetic modeling to inform formulation and clinical development for a compound with pH-dependent solubility.

Chung J, Alvarez-Nunez F, Chow V, Daurio D, Davis J, Dodds M, Emery M, Litwiler K, Paccaly A, Peng J, Rock B, Wienkers L, Yang C, Yu Z, Wahlstrom J. Chung J, et al. J Pharm Sci. 2015 Apr;104(4):1522-32. doi: 10.1002/jps.24339. Epub 2015 Jan 15. J Pharm Sci. 2015. PMID: 25641187

5

Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose.

Leil TA, Feng Y, Zhang L, Paccaly A, Mohan P, Pfister M. Leil TA, et al. Clin Pharmacol Ther. 2010 Sep;88(3):375-82. doi: 10.1038/clpt.2010.106. Epub 2010 Aug 4. Clin Pharmacol Ther. 2010. PMID: 20686477

6

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, with tirofiban in healthy volunteers.

Hinder M, Paccaly A, Frick A, Shukla U, Simcox K, Miller B, Gebauer A. Hinder M, et al. Thromb Haemost. 2005 Apr;93(4):794-5. Thromb Haemost. 2005. PMID: 15841331 Clinical Trial. No abstract available.

7

Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for phase 2/3 simulation of exposure.

Paccaly A, Frick A, Rohatagi S, Liu J, Shukla U, Rosenburg R, Hinder M, Jensen BK. Paccaly A, et al. J Clin Pharmacol. 2006 Jan;46(1):37-44. doi: 10.1177/0091270005281817. J Clin Pharmacol. 2006. PMID: 16397282 Clinical Trial.

8

Pharmacokinetic/pharmacodynamic relationships for otamixaban, a direct factor Xa inhibitor, in healthy subjects.

Paccaly A, Frick A, Ozoux ML, Chu V, Rosenburg R, Hinder M, Shukla U, Jensen BK. Paccaly A, et al. J Clin Pharmacol. 2006 Jan;46(1):45-51. doi: 10.1177/0091270005281818. J Clin Pharmacol. 2006. PMID: 16397283 Clinical Trial.

9

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid.

Hinder M, Frick A, Rosenburg R, Hesse G, Ozoux ML, Laux V, Scholtz H, Gebauer A, Paccaly A. Hinder M, et al. Thromb Haemost. 2006 Feb;95(2):224-8. doi: 10.1160/TH05-08-0592. Thromb Haemost. 2006. PMID: 16493482 Clinical Trial.

10

Direct and rapid inhibition of factor Xa by otamixaban: a pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease.

Hinder M, Frick A, Jordaan P, Hesse G, Gebauer A, Maas J, Paccaly A. Hinder M, et al. Clin Pharmacol Ther. 2006 Dec;80(6):691-702. doi: 10.1016/j.clpt.2006.09.002. Clin Pharmacol Ther. 2006. PMID: 17178269 Clinical Trial.

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