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Page 1
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Chen H, Blizzard TA, Kim S, Wu J, Young K, Park YW, Ogawa AM, Raghoobar S, Painter RE, Wisniewski D, Hairston N, Fitzgerald P, Sharma N, Scapin G, Lu J, Hermes J, Hammond ML. Chen H, et al. Among authors: hermes j. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4267-70. doi: 10.1016/j.bmcl.2011.05.065. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21676616
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.
Blizzard TA, Chen H, Kim S, Wu J, Young K, Park YW, Ogawa A, Raghoobar S, Painter RE, Hairston N, Lee SH, Misura A, Felcetto T, Fitzgerald P, Sharma N, Lu J, Ha S, Hickey E, Hermes J, Hammond ML. Blizzard TA, et al. Among authors: hermes j. Bioorg Med Chem Lett. 2010 Feb 1;20(3):918-21. doi: 10.1016/j.bmcl.2009.12.069. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20044254
Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.
Blizzard TA, Chen H, Kim S, Wu J, Bodner R, Gude C, Imbriglio J, Young K, Park YW, Ogawa A, Raghoobar S, Hairston N, Painter RE, Wisniewski D, Scapin G, Fitzgerald P, Sharma N, Lu J, Ha S, Hermes J, Hammond ML. Blizzard TA, et al. Among authors: hermes j. Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5. doi: 10.1016/j.bmcl.2013.12.101. Epub 2014 Jan 3. Bioorg Med Chem Lett. 2014. PMID: 24433862
Disubstituted pyrimidines as Lck inhibitors.
Hunt JA, Beresis RT, Goulet JL, Holmes MA, Hong XJ, Kovacs E, Mills SG, Ruzek RD, Wong F, Hermes JD, Park YW, Salowe SP, Sonatore LM, Wu L, Woods A, Zaller DM, Sinclair PJ. Hunt JA, et al. Among authors: hermes jd. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5440-3. doi: 10.1016/j.bmcl.2009.07.102. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19674899
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Among authors: hermes jd. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT. Xiong Y, et al. Among authors: hermes jd. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. doi: 10.1016/j.bmcl.2005.10.088. Epub 2005 Dec 9. Bioorg Med Chem Lett. 2006. PMID: 16338135
Anthrax lethal factor inhibition.
Shoop WL, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Felcetto T, Michael BF, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Patel SB, Wisniewski D, Scapin G, Salowe SP, Zaller DM, Chapman KT, Scolnick EM, Schmatz DM, Bartizal K, MacCoss M, Hermes JD. Shoop WL, et al. Among authors: hermes jd. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7958-63. doi: 10.1073/pnas.0502159102. Epub 2005 May 23. Proc Natl Acad Sci U S A. 2005. PMID: 15911756 Free PMC article.
195 results