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Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Soberanes S, et al. Among authors: urich d. J Biol Chem. 2009 Jan 23;284(4):2176-86. doi: 10.1074/jbc.M808844200. Epub 2008 Nov 25. J Biol Chem. 2009. PMID: 19033436 Free PMC article.
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS. Budinger GR, et al. Among authors: urich d. Am J Respir Crit Care Med. 2011 Apr 15;183(8):1043-54. doi: 10.1164/rccm.201002-0181OC. Epub 2010 Oct 19. Am J Respir Crit Care Med. 2011. PMID: 20959557 Free PMC article.
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.
Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM. Budinger GR, et al. Among authors: urich d. PLoS One. 2011 Apr 11;6(4):e18525. doi: 10.1371/journal.pone.0018525. PLoS One. 2011. PMID: 21494547 Free PMC article.
Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.
Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC. Urich D, et al. J Cell Sci. 2011 Sep 1;124(Pt 17):2927-37. doi: 10.1242/jcs.080911. J Cell Sci. 2011. PMID: 21878500 Free PMC article.
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.
Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. Chiarella SE, et al. Among authors: urich d. J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27. J Clin Invest. 2014. PMID: 24865431 Free PMC article.
The effect of rosuvastatin in a murine model of influenza A infection.
Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM. Radigan KA, et al. Among authors: urich d. PLoS One. 2012;7(4):e35788. doi: 10.1371/journal.pone.0035788. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22536437 Free PMC article.
27 results