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Page 1
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, Gilbert B, Lippens S, De Groote P, Roelandt R, Van Damme P, Gevaert K, Presland RB, Takahara H, Puppels G, Caspers P, Vandenabeele P, Declercq W. Hoste E, et al. Among authors: roelandt r. J Invest Dermatol. 2011 Nov;131(11):2233-41. doi: 10.1038/jid.2011.153. Epub 2011 Jun 9. J Invest Dermatol. 2011. PMID: 21654840 Free article.
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W, Agostinis P, Vanden Berghe T, Lippens S, Vandenabeele P. Wirawan E, et al. Among authors: roelandt r. Cell Death Dis. 2010;1(1):e18. doi: 10.1038/cddis.2009.16. Cell Death Dis. 2010. PMID: 21364619 Free PMC article.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.
Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, Vandenabeele P. Takahashi N, et al. Among authors: roelandt r. Cell Death Dis. 2012 Nov 29;3(11):e437. doi: 10.1038/cddis.2012.176. Cell Death Dis. 2012. PMID: 23190609 Free PMC article.
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.
Vanden Berghe T, Demon D, Bogaert P, Vandendriessche B, Goethals A, Depuydt B, Vuylsteke M, Roelandt R, Van Wonterghem E, Vandenbroecke J, Choi SM, Meyer E, Krautwald S, Declercq W, Takahashi N, Cauwels A, Vandenabeele P. Vanden Berghe T, et al. Among authors: roelandt r. Am J Respir Crit Care Med. 2014 Feb 1;189(3):282-91. doi: 10.1164/rccm.201308-1535OC. Am J Respir Crit Care Med. 2014. PMID: 24456467
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, Bertin J, Gough PJ, Savvides S, Martinou JC, Bertrand MJ, Vandenabeele P. Dondelinger Y, et al. Among authors: roelandt r. Cell Rep. 2014 May 22;7(4):971-81. doi: 10.1016/j.celrep.2014.04.026. Epub 2014 May 9. Cell Rep. 2014. PMID: 24813885 Free article.
Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay.
Cleenewerck M, Grootaert MOJ, Gladysz R, Adriaenssens Y, Roelandt R, Joossens J, Lambeir AM, De Meyer GRY, Declercq W, Augustyns K, Martinet W, Van der Veken P. Cleenewerck M, et al. Among authors: roelandt r. Eur J Med Chem. 2016 Nov 10;123:631-638. doi: 10.1016/j.ejmech.2016.07.073. Epub 2016 Jul 31. Eur J Med Chem. 2016. PMID: 27517808
40 results