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Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining.
Bergs JW, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJ, Kanaar R, Aten JA, Franken NA. Bergs JW, et al. Among authors: aten ja. DNA Repair (Amst). 2013 Jan 1;12(1):38-45. doi: 10.1016/j.dnarep.2012.10.008. Epub 2012 Dec 11. DNA Repair (Amst). 2013. PMID: 23237939
Chromatin mobility is increased at sites of DNA double-strand breaks.
Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NA, Aten JA. Krawczyk PM, et al. Among authors: aten ja. J Cell Sci. 2012 May 1;125(Pt 9):2127-33. doi: 10.1242/jcs.089847. Epub 2012 Feb 10. J Cell Sci. 2012. PMID: 22328517
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA. Krawczyk PM, et al. Among authors: aten ja. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9851-6. doi: 10.1073/pnas.1101053108. Epub 2011 May 9. Proc Natl Acad Sci U S A. 2011. PMID: 21555554 Free PMC article.
218 results