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The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis.
Biczó G, Hegyi P, Dósa S, Shalbuyeva N, Berczi S, Sinervirta R, Hracskó Z, Siska A, Kukor Z, Jármay K, Venglovecz V, Varga IS, Iványi B, Alhonen L, Wittmann T, Gukovskaya A, Takács T, Rakonczay Z Jr. Biczó G, et al. Among authors: sinervirta r. Antioxid Redox Signal. 2011 Nov 15;15(10):2669-81. doi: 10.1089/ars.2011.4065. Epub 2011 Jul 18. Antioxid Redox Signal. 2011. PMID: 21644850 Free PMC article.
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
Rasanen TL, Alhonen L, Sinervirta R, Keinanen T, Herzig KH, Suppola S, Khomutov AR, Vepsalainen J, Janne J. Rasanen TL, et al. Among authors: sinervirta r. J Biol Chem. 2002 Oct 18;277(42):39867-72. doi: 10.1074/jbc.M205967200. Epub 2002 Aug 13. J Biol Chem. 2002. PMID: 12181316 Free article.
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyamines spermidine and spermine due to inducible activation of their catabolism (Alhonen, L., Parkkinen, J. J., Keinanen, T., Sinervirta …
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyam …
activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.
Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. Hyvönen MT, et al. Among authors: sinervirta r. Am J Pathol. 2006 Jan;168(1):115-22. doi: 10.2353/ajpath.2006.050518. Am J Pathol. 2006. PMID: 16400014 Free PMC article.
41 results