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Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. Vetrivel KS, et al. Among authors: wagner sl. J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3. J Biol Chem. 2011. PMID: 21642424 Free PMC article.
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Hiltunen M, et al. Among authors: wagner sl. J Biol Chem. 2006 Oct 27;281(43):32240-53. doi: 10.1074/jbc.M603106200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945923 Free article.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: wagner sl. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. Weissmiller AM, et al. Among authors: wagner sl. PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015. PLoS One. 2015. PMID: 25710492 Free PMC article.
129 results