Prabhakar R - Search Results

1

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. Vetrivel KS, et al. Among authors: prabhakar r. J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3. J Biol Chem. 2011. PMID: 21642424 Free PMC article.

2

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme.

Barman A, Schürer S, Prabhakar R. Barman A, et al. Among authors: prabhakar r. Biochemistry. 2011 May 24;50(20):4337-49. doi: 10.1021/bi200081h. Epub 2011 May 2. Biochemistry. 2011. PMID: 21500768

3

Protonation states of the catalytic dyad of β-secretase (BACE1) in the presence of chemically diverse inhibitors: a molecular docking study.

Barman A, Prabhakar R. Barman A, et al. Among authors: prabhakar r. J Chem Inf Model. 2012 May 25;52(5):1275-87. doi: 10.1021/ci200611t. Epub 2012 May 16. J Chem Inf Model. 2012. PMID: 22545704

4

Elucidating the catalytic mechanism of β-secretase (BACE1): a quantum mechanics/molecular mechanics (QM/MM) approach.

Barman A, Prabhakar R. Barman A, et al. Among authors: prabhakar r. J Mol Graph Model. 2013 Mar;40:1-9. doi: 10.1016/j.jmgm.2012.12.010. Epub 2013 Jan 5. J Mol Graph Model. 2013. PMID: 23337572

5

Computational insights into aspartyl protease activity of presenilin 1 (PS1) generating Alzheimer amyloid beta-peptides (Abeta40 and Abeta42).

Singh R, Barman A, Prabhakar R. Singh R, et al. Among authors: prabhakar r. J Phys Chem B. 2009 Mar 12;113(10):2990-9. doi: 10.1021/jp811154w. J Phys Chem B. 2009. PMID: 19708161

6

Dimerization of the full-length Alzheimer amyloid β-peptide (Aβ42) in explicit aqueous solution: a molecular dynamics study.

Zhu X, Bora RP, Barman A, Singh R, Prabhakar R. Zhu X, et al. Among authors: prabhakar r. J Phys Chem B. 2012 Apr 19;116(15):4405-16. doi: 10.1021/jp210019h. Epub 2012 Apr 6. J Phys Chem B. 2012. PMID: 22448932

7

Which one among aspartyl protease, metallopeptidase, and artificial metallopeptidase is the most efficient catalyst in peptide hydrolysis?

Bora RP, Barman A, Zhu X, Ozbil M, Prabhakar R. Bora RP, et al. Among authors: prabhakar r. J Phys Chem B. 2010 Aug 26;114(33):10860-75. doi: 10.1021/jp104294x. J Phys Chem B. 2010. PMID: 20669962

8

Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -Secretase.

Barman A, Prabhakar R. Barman A, et al. Among authors: prabhakar r. Scientifica (Cairo). 2014;2014:598728. doi: 10.1155/2014/598728. Epub 2014 Sep 18. Scientifica (Cairo). 2014. PMID: 25309776 Free PMC article. Review.

9

Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme: a DFT approach.

Zhu X, Barman A, Ozbil M, Zhang T, Li S, Prabhakar R. Zhu X, et al. Among authors: prabhakar r. J Biol Inorg Chem. 2012 Feb;17(2):209-22. doi: 10.1007/s00775-011-0843-2. Epub 2011 Sep 15. J Biol Inorg Chem. 2012. PMID: 21918843

10

Mechanisms of peptide hydrolysis by aspartyl and metalloproteases.

Paul TJ, Barman A, Ozbil M, Bora RP, Zhang T, Sharma G, Hoffmann Z, Prabhakar R. Paul TJ, et al. Among authors: prabhakar r. Phys Chem Chem Phys. 2016 Sep 14;18(36):24790-24801. doi: 10.1039/c6cp02097f. Phys Chem Chem Phys. 2016. PMID: 27711373

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