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Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells.
Nguyen DH, Webb DJ, Catling AD, Song Q, Dhakephalkar A, Weber MJ, Ravichandran KS, Gonias SL. Nguyen DH, et al. Among authors: gonias sl. J Biol Chem. 2000 Jun 23;275(25):19382-8. doi: 10.1074/jbc.M909575199. J Biol Chem. 2000. PMID: 10777511 Free article.
243 results