Takeuchi T - Search Results

1

Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.

Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K, Asai A, Asada N, Kitaura K, Fujii N. Takeuchi T, et al. J Med Chem. 2011 Jul 14;54(13):4839-46. doi: 10.1021/jm200448n. Epub 2011 Jun 7. J Med Chem. 2011. PMID: 21599002

2

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents.

Mizuhara T, Kato T, Hirai A, Kurihara H, Shimada Y, Taniguchi M, Maeta H, Togami H, Shimura K, Matsuoka M, Okazaki S, Takeuchi T, Ohno H, Oishi S, Fujii N. Mizuhara T, et al. Among authors: takeuchi t. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4557-61. doi: 10.1016/j.bmcl.2013.06.026. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23845222

3

Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.

Takeuchi T, Oishi S, Kaneda M, Misu R, Ohno H, Sawada J, Asai A, Nakamura S, Nakanishi I, Fujii N. Takeuchi T, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3171-9. doi: 10.1016/j.bmc.2014.04.008. Epub 2014 Apr 13. Bioorg Med Chem. 2014. PMID: 24794744 Free article.

4

Kinesin spindle protein inhibitors with diaryl amine scaffolds: crystal packing analysis for improved aqueous solubility.

Takeuchi T, Oishi S, Kaneda M, Ohno H, Nakamura S, Nakanishi I, Yamane M, Sawada J, Asai A, Fujii N. Takeuchi T, et al. ACS Med Chem Lett. 2014 Mar 10;5(5):566-71. doi: 10.1021/ml500016j. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900881 Free PMC article.

5

Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor.

Takenaga M, Yamamoto Y, Takeuchi T, Ohta Y, Tokura Y, Hamaguchi A, Asai D, Nakashima H, Oishi S, Fujii N. Takenaga M, et al. Among authors: takeuchi t. Biochem Biophys Res Commun. 2015 Jul 31;463(3):222-8. doi: 10.1016/j.bbrc.2015.05.029. Epub 2015 May 19. Biochem Biophys Res Commun. 2015. PMID: 25998394

6

Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).

Sawada JI, Osawa A, Takeuchi T, Kaneda M, Oishi S, Fujii N, Asai A, Tanino K, Namba K. Sawada JI, et al. Among authors: takeuchi t. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5765-5769. doi: 10.1016/j.bmcl.2016.10.047. Epub 2016 Oct 15. Bioorg Med Chem Lett. 2016. PMID: 27793568

7

Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.

Ushiyama F, Amada H, Mihara Y, Takeuchi T, Tanaka-Yamamoto N, Mima M, Kamitani M, Wada R, Tamura Y, Endo M, Masuko A, Takata I, Hitaka K, Sugiyama H, Ohtake N. Ushiyama F, et al. Among authors: takeuchi t. Bioorg Med Chem. 2020 Nov 15;28(22):115776. doi: 10.1016/j.bmc.2020.115776. Epub 2020 Sep 22. Bioorg Med Chem. 2020. PMID: 33032189

8

Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties.

Yamaguchi-Sasaki T, Kawaguchi T, Okada A, Tokura S, Tanaka-Yamamoto N, Takeuchi T, Ogata Y, Takahashi R, Kurimoto-Tsuruta R, Tamaoki T, Sugaya Y, Abe-Kumasaka T, Arikawa K, Yoshida I, Sugiyama H, Kanuma K, Yoshinaga M. Yamaguchi-Sasaki T, et al. Among authors: takeuchi t. Bioorg Med Chem. 2020 Dec 15;28(24):115818. doi: 10.1016/j.bmc.2020.115818. Epub 2020 Oct 31. Bioorg Med Chem. 2020. PMID: 33190073

9

Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.

Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M, Mima M, Toki H, Ohkubo M, Nozoe A, Kakinuma H. Takeuchi T, et al. J Med Chem. 2022 Jun 23;65(12):8493-8510. doi: 10.1021/acs.jmedchem.2c00613. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35687819

10

Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.

Takeuchi T, Nomura Y, Tamita T, Nishikawa R, Kakinuma H, Kojima N, Hitaka K, Tamura Y, Kamitani M, Mima M, Nozoe A, Hayashi M. Takeuchi T, et al. J Med Chem. 2023 Jan 12;66(1):822-836. doi: 10.1021/acs.jmedchem.2c01698. Epub 2023 Jan 3. J Med Chem. 2023. PMID: 36595440

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