Kolkhof P - Search Results

1

Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors.

Griebenow N, Buchmueller A, Kolkhof P, Schamberger J, Bischoff H. Griebenow N, et al. Among authors: kolkhof p. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3648-53. doi: 10.1016/j.bmcl.2011.04.092. Epub 2011 Apr 29. Bioorg Med Chem Lett. 2011. PMID: 21576018

2

Finerenone protects against progression of kidney and cardiovascular damage in a model of type 1 diabetes through modulation of proinflammatory and osteogenic factors.

Sanz-Gómez M, Manzano-Lista FJ, Vega-Martín E, González-Moreno D, Alcalá M, Gil-Ortega M, Somoza B, Pizzamiglio C, Ruilope LM, Aránguez I, Kolkhof P, Kreutz R, Fernández-Alfonso MS. Sanz-Gómez M, et al. Among authors: kolkhof p. Biomed Pharmacother. 2023 Dec;168:115661. doi: 10.1016/j.biopha.2023.115661. Epub 2023 Oct 11. Biomed Pharmacother. 2023. PMID: 37832406 Free article.

3

Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis.

Perakakis N, Bornstein SR, Birkenfeld AL, Linkermann A, Demir M, Anker SD, Filippatos G, Pitt B, Rossing P, Ruilope LM, Kolkhof P, Lawatscheck R, Scott C, Bakris GL; FIDELIO-DKD and FIGARO-DKD investigators. Perakakis N, et al. Among authors: kolkhof p. Diabetes Obes Metab. 2024 Jan;26(1):191-200. doi: 10.1111/dom.15305. Epub 2023 Oct 10. Diabetes Obes Metab. 2024. PMID: 37814928

4

Cardiorenal Outcomes with Finerenone in Asian Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELIO-DKD post hoc Analysis.

Koya D, Anker SD, Ruilope LM, Rossing P, Liu Z, Lee BW, Lee CT, Scott C, Kolkhof P, Lawatscheck R, Wang L, Joseph A, Pitt B; FIDELIO-DKD Investigators. Koya D, et al. Among authors: kolkhof p. Am J Nephrol. 2023;54(9-10):370-378. doi: 10.1159/000532102. Epub 2023 Sep 14. Am J Nephrol. 2023. PMID: 37708857 Free article. Clinical Trial.

5

Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.

Griebenow N, Bärfacker L, Meier H, Schneider D, Teusch N, Lustig K, Kast R, Kolkhof P. Griebenow N, et al. Among authors: kolkhof p. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5891-4. doi: 10.1016/j.bmcl.2010.07.095. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20728355

6

Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors.

Griebenow N, Flessner T, Buchmueller A, Raabe M, Bischoff H, Kolkhof P. Griebenow N, et al. Among authors: kolkhof p. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2554-8. doi: 10.1016/j.bmcl.2011.02.004. Epub 2011 Feb 17. Bioorg Med Chem Lett. 2011. PMID: 21396815

7

A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

Fagart J, Hillisch A, Huyet J, Bärfacker L, Fay M, Pleiss U, Pook E, Schäfer S, Rafestin-Oblin ME, Kolkhof P. Fagart J, et al. Among authors: kolkhof p. J Biol Chem. 2010 Sep 24;285(39):29932-40. doi: 10.1074/jbc.M110.131342. Epub 2010 Jul 22. J Biol Chem. 2010. PMID: 20650892 Free PMC article.

8

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.

Wunder F, Tinel H, Kast R, Geerts A, Becker EM, Kolkhof P, Hütter J, Ergüden J, Härter M. Wunder F, et al. Among authors: kolkhof p. Br J Pharmacol. 2010 May;160(2):399-409. doi: 10.1111/j.1476-5381.2010.00730.x. Br J Pharmacol. 2010. PMID: 20423349 Free PMC article.

9

Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics.

Kolkhof P, Borden SA. Kolkhof P, et al. Mol Cell Endocrinol. 2012 Mar 24;350(2):310-7. doi: 10.1016/j.mce.2011.06.025. Epub 2011 Jul 13. Mol Cell Endocrinol. 2012. PMID: 21771637 Review.

10

Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases.

Bärfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Pérez S, Heckroth H, Nitsche A, Ergüden JK, Gielen-Haertwig H, Schlemmer KH, Mittendorf J, Paulsen H, Platzek J, Kolkhof P. Bärfacker L, et al. Among authors: kolkhof p. ChemMedChem. 2012 Aug;7(8):1385-403. doi: 10.1002/cmdc.201200081. Epub 2012 Jul 12. ChemMedChem. 2012. PMID: 22791416

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