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Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG. Hakimi M, et al. J Neural Transm (Vienna). 2011 May;118(5):795-808. doi: 10.1007/s00702-011-0653-2. Epub 2011 May 7. J Neural Transm (Vienna). 2011. PMID: 21552986 Free PMC article.
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG. Shutinoski B, et al. Among authors: hakimi m. Sci Transl Med. 2019 Sep 25;11(511):eaas9292. doi: 10.1126/scitranslmed.aas9292. Sci Transl Med. 2019. PMID: 31554740
α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system.
Mollenhauer B, Trautmann E, Otte B, Ng J, Spreer A, Lange P, Sixel-Döring F, Hakimi M, Vonsattel JP, Nussbaum R, Trenkwalder C, Schlossmacher MG. Mollenhauer B, et al. Among authors: hakimi m. J Neural Transm (Vienna). 2012 Jul;119(7):739-46. doi: 10.1007/s00702-012-0784-0. Epub 2012 Mar 18. J Neural Transm (Vienna). 2012. PMID: 22426833 Free PMC article.
Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination.
Ten Hoeve AL, Rodriguez ME, Säflund M, Michel V, Magimel L, Ripoll A, Yu T, Hakimi M-A, Saeij JPJ, Ozata DM, Barragan A. Ten Hoeve AL, et al. Among authors: hakimi m a. mBio. 2024 Oct 16;15(10):e0214024. doi: 10.1128/mbio.02140-24. Epub 2024 Aug 29. mBio. 2024. PMID: 39207098 Free PMC article.
459 results